GFI1 Antibody - N-terminal region (ARP32557_P050)

Data Sheet
 
Product Number ARP32557_P050
Product Page www.avivasysbio.com/gfi1-antibody-n-terminal-region-arp32557-p050.html
Name GFI1 Antibody - N-terminal region (ARP32557_P050)
Protein Size (# AA) 422 amino acids
Molecular Weight 45kDa
NCBI Gene Id 2672
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Growth factor independent 1 transcription repressor
Alias Symbols SCN2, GFI-1, GFI1A, ZNF163
Peptide Sequence Synthetic peptide located within the following region: VPAPSRADSTSNAGGAKAEPRDRLSPESQLTEAPDRASASPDSCEGSVCE
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Doan,L.L., et al., (2004) Nucleic Acids Res. 32 (8), 2508-2519
Description of Target GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Protein Interactions RELA; SPI1; CHAF1A; PICK1; PIAS2; RCOR1; KDM1A; HDAC2; PRDM5; HDAC1; EHMT2; PIAS3; RUNX1T1; ARIH2; UBC;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-GFI1 (ARP32557_P050) antibody
Blocking Peptide For anti-GFI1 (ARP32557_P050) antibody is Catalog # AAP32557 (Previous Catalog # AAPP32106)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human GFI1
Uniprot ID Q99684
Protein Name Zinc finger protein Gfi-1
Protein Accession # NP_005254
Purification Affinity Purified
Nucleotide Accession # NM_005263
Tested Species Reactivity Human
Gene Symbol GFI1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 79%; Rat: 100%
Image 1
Human Lung
WB Suggested Anti-GFI1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Human Lung
 

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