Product Number |
ARP32557_P050 |
Product Page |
www.avivasysbio.com/gfi1-antibody-n-terminal-region-arp32557-p050.html |
Name |
GFI1 Antibody - N-terminal region (ARP32557_P050) |
Protein Size (# AA) |
422 amino acids |
Molecular Weight |
45kDa |
NCBI Gene Id |
2672 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Growth factor independent 1 transcription repressor |
Alias Symbols |
SCN2, GFI-1, GFI1A, ZNF163 |
Peptide Sequence |
Synthetic peptide located within the following region: VPAPSRADSTSNAGGAKAEPRDRLSPESQLTEAPDRASASPDSCEGSVCE |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Doan,L.L., et al., (2004) Nucleic Acids Res. 32 (8), 2508-2519 |
Description of Target |
GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. |
Protein Interactions |
RELA; SPI1; CHAF1A; PICK1; PIAS2; RCOR1; KDM1A; HDAC2; PRDM5; HDAC1; EHMT2; PIAS3; RUNX1T1; ARIH2; UBC; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-GFI1 (ARP32557_P050) antibody |
Blocking Peptide |
For anti-GFI1 (ARP32557_P050) antibody is Catalog # AAP32557 (Previous Catalog # AAPP32106) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human GFI1 |
Uniprot ID |
Q99684 |
Protein Name |
Zinc finger protein Gfi-1 |
Protein Accession # |
NP_005254 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_005263 |
Tested Species Reactivity |
Human |
Gene Symbol |
GFI1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 79%; Rat: 100% |
Image 1 | Human Lung
| WB Suggested Anti-GFI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human Lung |
|