Product Number |
ARP32466_T100 |
Product Page |
www.avivasysbio.com/pcaf-antibody-n-terminal-region-arp32466-t100.html |
Name |
PCAF Antibody - N-terminal region (ARP32466_T100) |
Protein Size (# AA) |
832 amino acids |
Molecular Weight |
93kDa |
NCBI Gene Id |
8850 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
K(lysine) acetyltransferase 2B |
Alias Symbols |
CAF, PCAF, P/CAF |
Peptide Sequence |
Synthetic peptide located within the following region: LFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAK |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Chu,B.Y., Biochem. J. 392 (PT 3), 589-599 (2005) |
Description of Target |
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. |
Protein Interactions |
MDM2; HNRNPD; ACLY; KLF2; E2F1; VHL; IRF1; TAL1; TAF12; TAF10; TAF9; TADA2A; RB1; HIST1H1B; TAF5L; TAF6L; TADA3; SUPT3H; TWIST1; PDK1; AKT1; UBC; SIAH2; UBE2D3; UBE2D1; TP73; TP53; SRC; PGR; YEATS2; MBIP; WDR5; PTEN; DR1; HIF1A; HIST2H3C; CHEK2; HIST1H4A; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-KAT2B (ARP32466_T100) antibody |
Blocking Peptide |
For anti-KAT2B (ARP32466_T100) antibody is Catalog # AAP32466 (Previous Catalog # AAPP03464) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human PCAF |
Uniprot ID |
Q92831 |
Protein Name |
Histone acetyltransferase KAT2B |
Protein Accession # |
NP_003875 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_003884 |
Tested Species Reactivity |
Human |
Gene Symbol |
KAT2B |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 90% |
Image 1 | Human HepG2
| WB Suggested Anti-PCAF Antibody Titration: 2.5ug/ml Positive Control: HepG2 cell lysate |
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