PCAF Antibody - N-terminal region (ARP32466_T100)

Data Sheet
 
Product Number ARP32466_T100
Product Page www.avivasysbio.com/pcaf-antibody-n-terminal-region-arp32466-t100.html
Name PCAF Antibody - N-terminal region (ARP32466_T100)
Protein Size (# AA) 832 amino acids
Molecular Weight 93kDa
NCBI Gene Id 8850
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name K(lysine) acetyltransferase 2B
Alias Symbols CAF, PCAF, P/CAF
Peptide Sequence Synthetic peptide located within the following region: LFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Chu,B.Y., Biochem. J. 392 (PT 3), 589-599 (2005)
Description of Target CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Protein Interactions MDM2; HNRNPD; ACLY; KLF2; E2F1; VHL; IRF1; TAL1; TAF12; TAF10; TAF9; TADA2A; RB1; HIST1H1B; TAF5L; TAF6L; TADA3; SUPT3H; TWIST1; PDK1; AKT1; UBC; SIAH2; UBE2D3; UBE2D1; TP73; TP53; SRC; PGR; YEATS2; MBIP; WDR5; PTEN; DR1; HIF1A; HIST2H3C; CHEK2; HIST1H4A;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-KAT2B (ARP32466_T100) antibody
Blocking Peptide For anti-KAT2B (ARP32466_T100) antibody is Catalog # AAP32466 (Previous Catalog # AAPP03464)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PCAF
Uniprot ID Q92831
Protein Name Histone acetyltransferase KAT2B
Protein Accession # NP_003875
Purification Protein A purified
Nucleotide Accession # NM_003884
Tested Species Reactivity Human
Gene Symbol KAT2B
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 90%
Image 1
Human HepG2
WB Suggested Anti-PCAF Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate
 

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