Product Number |
ARP32452_P050 |
Product Page |
www.avivasysbio.com/sirt4-antibody-n-terminal-region-arp32452-p050.html |
Name |
SIRT4 Antibody - N-terminal region (ARP32452_P050) |
Protein Size (# AA) |
314 amino acids |
Molecular Weight |
35kDa |
NCBI Gene Id |
23409 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Sirtuin 4 |
Alias Symbols |
SIR2L4 |
Peptide Sequence |
Synthetic peptide located within the following region: ASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYAR |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Ahuja,N., (2007) J. Biol. Chem. 282 (46), 33583-33592 |
Description of Target |
SIRT4 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT4 is included in class IV of the sirtuin family. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. |
Protein Interactions |
SKP2; Glud1; UBC; SIRT3; IDE; SLC25A6; SLC25A5; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SIRT4 (ARP32452_P050) antibody |
Blocking Peptide |
For anti-SIRT4 (ARP32452_P050) antibody is Catalog # AAP32452 (Previous Catalog # AAPP03448) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT4 |
Uniprot ID |
Q9Y6E7 |
Protein Name |
NAD-dependent protein deacetylase sirtuin-4 |
Protein Accession # |
NP_036372 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_012240 |
Tested Species Reactivity |
Human |
Gene Symbol |
SIRT4 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Sheep, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100% |
Image 1 | Human HepG2
| Host: Rabbit Target Name: SIRT4 Sample Tissue: Human HepG2 Antibody Dilution: 1.0ug/ml |
|
Image 2 | HepG2, THP-1
| Host: Rabbit Target: SIRT4 Positive control (+): HepG2 (HG) Negative control (-): THP-1 (N30) Antibody concentration: 3ug/ml |
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