Product Number |
ARP32384_P050 |
Product Page |
www.avivasysbio.com/sirt2-antibody-n-terminal-region-arp32384-p050.html |
Name |
SIRT2 Antibody - N-terminal region (ARP32384_P050) |
Protein Size (# AA) |
389 amino acids |
Molecular Weight |
43kDa |
NCBI Gene Id |
22933 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Sirtuin 2 |
Alias Symbols |
SIR2, SIR2L, SIR2L2 |
Peptide Sequence |
Synthetic peptide located within the following region: MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLS |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Borra,M.T., et al., (2004) Biochemistry 43 (30), 9877-9887 |
Description of Target |
SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by SIRT2 is included in class I of the sirtuin family. |
Protein Interactions |
ACLY; SIRT1; UBC; ING1; EP300; CBLB; CBL; XPO1; CDC20; FZR1; RUNX3; PCK1; FOXO1; HDAC6; tat; RBP1; HIST1H3A; NUDT21; PAPOLA; DNAJB8; DNAJB6; SP140; KAT2B; CDC14B; KAT2A; TUBA4A; HOXA10; TUBB; KRT78; RTN4; PHB2; SPOP; ELL; SARS; GYS1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SIRT2 (ARP32384_P050) antibody |
Blocking Peptide |
For anti-SIRT2 (ARP32384_P050) antibody is Catalog # AAP32384 (Previous Catalog # AAPP03374) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT2 |
Uniprot ID |
Q8IXJ6 |
Protein Name |
NAD-dependent protein deacetylase sirtuin-2 |
Publications |
Benavente, C. A., Schnell, S. A. & Jacobson, E. L. Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. PLoS One 7, e42276 (2012). 22860104 |
Protein Accession # |
NP_036369 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_012237 |
Tested Species Reactivity |
Human |
Gene Symbol |
SIRT2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 92%; Dog: 82%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Mouse: 92%; Pig: 92%; Rabbit: 100%; Rat: 77%; Yeast: 79% |
Image 1 | Human Brain
| WB Suggested Anti-SIRT2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human brain |
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