SIRT2 Antibody - N-terminal region (ARP32384_P050)

Data Sheet
 
Product Number ARP32384_P050
Product Page www.avivasysbio.com/sirt2-antibody-n-terminal-region-arp32384-p050.html
Name SIRT2 Antibody - N-terminal region (ARP32384_P050)
Protein Size (# AA) 389 amino acids
Molecular Weight 43kDa
NCBI Gene Id 22933
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Sirtuin 2
Alias Symbols SIR2, SIR2L, SIR2L2
Peptide Sequence Synthetic peptide located within the following region: MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLS
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Borra,M.T., et al., (2004) Biochemistry 43 (30), 9877-9887
Description of Target SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by SIRT2 is included in class I of the sirtuin family.
Protein Interactions ACLY; SIRT1; UBC; ING1; EP300; CBLB; CBL; XPO1; CDC20; FZR1; RUNX3; PCK1; FOXO1; HDAC6; tat; RBP1; HIST1H3A; NUDT21; PAPOLA; DNAJB8; DNAJB6; SP140; KAT2B; CDC14B; KAT2A; TUBA4A; HOXA10; TUBB; KRT78; RTN4; PHB2; SPOP; ELL; SARS; GYS1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-SIRT2 (ARP32384_P050) antibody
Blocking Peptide For anti-SIRT2 (ARP32384_P050) antibody is Catalog # AAP32384 (Previous Catalog # AAPP03374)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT2
Uniprot ID Q8IXJ6
Protein Name NAD-dependent protein deacetylase sirtuin-2
Publications

Benavente, C. A., Schnell, S. A. & Jacobson, E. L. Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. PLoS One 7, e42276 (2012). 22860104

Protein Accession # NP_036369
Purification Affinity Purified
Nucleotide Accession # NM_012237
Tested Species Reactivity Human
Gene Symbol SIRT2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 92%; Dog: 82%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Mouse: 92%; Pig: 92%; Rabbit: 100%; Rat: 77%; Yeast: 79%
Image 1
Human Brain
WB Suggested Anti-SIRT2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human brain
 

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