| Product Number |
ARP32341_P050 |
| Product Page |
www.avivasysbio.com/psmd4-antibody-c-terminal-region-arp32341-p050.html |
| Name |
PSMD4 Antibody - C-terminal region (ARP32341_P050) |
| Protein Size (# AA) |
377 amino acids |
| Molecular Weight |
41kDa |
| Subunit |
4 |
| NCBI Gene Id |
5710 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 |
| Alias Symbols |
AF, ASF, S5A, AF-1, MCB1, Rpn10, pUB-R5 |
| Peptide Sequence |
Synthetic peptide located within the following region: VMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Fujiwara,K., et al., (2004) J. Biol. Chem. 279 (6), 4760-4767 |
| Description of Target |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid. |
| Protein Interactions |
UBC; cdc20; XPC; SPRTN; PSMD14; MDM2; PSMC2; PSMA1; ADRM1; UBQLN1; TXNL1; PSMD3; PSMD2; PSMD1; PSMC6; PSMC4; PSMC1; UCHL5; RPS12; PSMD8; UBQLN4; VCP; GJA1; DIO2; SCHIP1; FBXO6; PARK2; UL76; FBXO25; LOC100044627; Gm4705; LOC677113; Rps6-ps4; Rpl34-ps1; Rpl |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PSMD4 (ARP32341_P050) antibody |
| Blocking Peptide |
For anti-PSMD4 (ARP32341_P050) antibody is Catalog # AAP32341 (Previous Catalog # AAPP03330) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human PSMD4 |
| Uniprot ID |
P55036 |
| Protein Name |
26S proteasome non-ATPase regulatory subunit 4 |
| Sample Type Confirmation |
PSMD4 is strongly supported by BioGPS gene expression data to be expressed in Raji |
| Protein Accession # |
NP_002801 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002810 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PSMD4 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100% |
| Image 1 | Human Raji
 | WB Suggested Anti-PSMD4 Antibody Titration: 0.2-1 ug/ml
Positive Control: Raji cell lysatePSMD4 is strongly supported by BioGPS gene expression data to be expressed in Human Raji cells |
|
| Image 2 | Human Brain
 | Rabbit Anti-PSMD4 Antibody
Catalog Number: ARP32341
Paraffin Embedded Tissue: Human neural cell
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X |
|
