Product Number |
ARP32247_T100 |
Product Page |
www.avivasysbio.com/elf3-antibody-middle-region-arp32247-t100.html |
Name |
ELF3 Antibody - middle region (ARP32247_T100) |
Protein Size (# AA) |
371 amino acids |
Molecular Weight |
41kDa |
NCBI Gene Id |
1999 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
Alias Symbols |
ERT, ESX, EPR-1, ESE-1 |
Peptide Sequence |
Synthetic peptide located within the following region: PGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSD |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Wang,H., (2004) J. Biol. Chem. 279 (24), 25241-25250 |
Description of Target |
ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP. |
Protein Interactions |
MED23; XRCC5; RPL6; XRCC6; EP300; CBR3; Jun; MYC; BTRC; UBC; PAK1; TAF9; SUMO2; TBP; EPS15; CREBBP; NFKB1; EGFR; ERBB2; EHF; GANAB; ISG15; TARS; P4HB; KRT82; KRT31; JAK1; EEF1D; DDX3X; CALR; ATIC; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-ELF3 (ARP32247_T100) antibody |
Blocking Peptide |
For anti-ELF3 (ARP32247_T100) antibody is Catalog # AAP32247 (Previous Catalog # AAPP03228) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human ELF3 |
Uniprot ID |
P78545 |
Protein Name |
ETS-related transcription factor Elf-3 |
Protein Accession # |
NP_004424 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_004433 |
Tested Species Reactivity |
Human |
Gene Symbol |
ELF3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 86%; Dog: 93%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100% |
Image 1 | Human Thymus
| WB Suggested Anti-ELF3 Antibody Titration: 2.5ug/ml ELISA Titer: 1:312500 Positive Control: Human Thymus |
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