Product Number |
ARP32008_P050 |
Product Page |
www.avivasysbio.com/smad7-antibody-n-terminal-region-arp32008-p050.html |
Name |
SMAD7 Antibody - N-terminal region (ARP32008_P050) |
Protein Size (# AA) |
426 amino acids |
Molecular Weight |
46kDa |
NCBI Gene Id |
4092 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
SMAD family member 7 |
Description |
|
Alias Symbols |
CRCS3, MADH7, MADH8 |
Peptide Sequence |
Synthetic peptide located within the following region: EEEGAGGGGGGGELRGEGATDSRAHGAGGGGPGRAGCCLGKAVRGAKGHH |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Komuro,A., et al., (2004) Oncogene 23 (41), 6914-6923 |
Description of Target |
Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition. |
Protein Interactions |
HDAC3; HDAC2; USP11; SMURF2; SMURF1; SKP2; MYC; Melk; HCVgp1; RNF111; KDM2A; SOX13; PIAS1; SOX7; UBE2O; MKL2; ASH1L; PIAS4; CXXC5; ZNF107; ZBTB11; HEYL; TTF2; UBC; TTF1; SOX5; MYOD1; XRCC6; CTNNB1; MAPK14; BAMBI; PPP1R15A; NEDD4L; STAMBP; YAP1; AXIN1; TP5 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SMAD7 (ARP32008_P050) antibody |
Blocking Peptide |
For anti-SMAD7 (ARP32008_P050) antibody is Catalog # AAP32008 |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD7 |
Uniprot ID |
O15105 |
Protein Name |
Mothers against decapentaplegic homolog 7 |
Publications |
Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions. Mar Drugs. 15, (2017). 28594374 |
Protein Accession # |
NP_005895 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_005904 |
Tested Species Reactivity |
Human |
Gene Symbol |
SMAD7 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Human: 100%; Mouse: 92%; Pig: 93%; Rabbit: 93%; Rat: 85% |
Image 1 | Human Lung
| Host: Rabbit Target Name: SMAD7 Sample Type: Human Lung Antibody Dilution: 1.0 ug/ml |
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Image 2 | Transfected 293 extracts
| WB Suggested Anti-SMAD7 Antibody Positive Control: Lane 1: 2ug Flag-SMAD7 transfected 293 extracts Primary Antibody Dilution : 1:500 Secondary Antibody : Goat anti-rabbit-HRP Secondry Antibody Dilution : 1:5000 Submitted by: Anonymous |
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