HNF4A Antibody - N-terminal region (ARP31946_P050)

Data Sheet
 
Product Number ARP31946_P050
Product Page www.avivasysbio.com/hnf4a-antibody-n-terminal-region-arp31946-p050.html
Name HNF4A Antibody - N-terminal region (ARP31946_P050)
Protein Size (# AA) 474 amino acids
Molecular Weight 53kDa
NCBI Gene Id 3172
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Hepatocyte nuclear factor 4, alpha
Description
Alias Symbols TCF, HNF4, MODY, FRTS4, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha
Peptide Sequence Synthetic peptide located within the following region: MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNA
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
Protein Interactions PIAS4; SUMO1; SUMO2; RNF4; SUB1; CREBBP; TBP; TAF9; TAF6; TADA2A; GTF2H1; GTF2B; ANP32B; MDM2; GPS2; PPARGC1A; HNF4A; NCOA6; SMAD4; SMAD3; PNRC2; COPS5; PNRC1; NR0B2; NRIP1; UBE2I; PROX1; NPPA; SREBF2; VDR; MAPK3; MAPK1; SIRT1; SREBF1; XPO1; SP1; HDAC3; T
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Enhanced Validation
WBY
SPR
YCHAROS
Datasheets/Manuals Printable datasheet for anti-HNF4A (ARP31946_P050) antibody
Blocking Peptide For anti-HNF4A (ARP31946_P050) antibody is Catalog # AAP31946
Immunogen The immunogen is a synthetic peptide directed towards the N-terminal region of Human HNF4A
Uniprot ID P41235
Protein Name Hepatocyte nuclear factor 4-alpha
Publications

AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation. Genome Biol. 14, R124 (2013). 24200198

Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Biol Chem. 289, 3105-13 (2014). 24318876

Faure, A. J. et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22, 2163-75 (2012). 22780989

Schmidt, D. et al. A CTCF-independent role for cohesin in tissue-specific transcription. Genome Res. 20, 578-88 (2010). 20219941

Protein Accession # NP_000448
Purification Affinity Purified
Nucleotide Accession # NM_000457
Tested Species Reactivity Human, Rat
Gene Symbol HNF4A
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 93%
Image 1
Human Lung Tumor
Host: Rabbit
Target Name: HNF4A
Sample Tissue: Human Lung Tumor
Antibody Dilution: 1.0ug/ml
Image 2
Rat Skeletal Muscle
Host: Rat
Target Name: HNF4A
Sample Tissue: Rat Skeletal Muscle
Antibody Dilution: 1ug/ml
 

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