Product Number |
ARP31946_P050 |
Product Page |
www.avivasysbio.com/hnf4a-antibody-n-terminal-region-arp31946-p050.html |
Name |
HNF4A Antibody - N-terminal region (ARP31946_P050) |
Protein Size (# AA) |
474 amino acids |
Molecular Weight |
53kDa |
NCBI Gene Id |
3172 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Hepatocyte nuclear factor 4, alpha |
Description |
|
Alias Symbols |
TCF, HNF4, MODY, FRTS4, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha |
Peptide Sequence |
Synthetic peptide located within the following region: MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNA |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. |
Protein Interactions |
PIAS4; SUMO1; SUMO2; RNF4; SUB1; CREBBP; TBP; TAF9; TAF6; TADA2A; GTF2H1; GTF2B; ANP32B; MDM2; GPS2; PPARGC1A; HNF4A; NCOA6; SMAD4; SMAD3; PNRC2; COPS5; PNRC1; NR0B2; NRIP1; UBE2I; PROX1; NPPA; SREBF2; VDR; MAPK3; MAPK1; SIRT1; SREBF1; XPO1; SP1; HDAC3; T |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
|
Datasheets/Manuals |
Printable datasheet for anti-HNF4A (ARP31946_P050) antibody |
Blocking Peptide |
For anti-HNF4A (ARP31946_P050) antibody is Catalog # AAP31946 |
Immunogen |
The immunogen is a synthetic peptide directed towards the N-terminal region of Human HNF4A |
Uniprot ID |
P41235 |
Protein Name |
Hepatocyte nuclear factor 4-alpha |
Publications |
AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation. Genome Biol. 14, R124 (2013). 24200198
Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Biol Chem. 289, 3105-13 (2014). 24318876
Faure, A. J. et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22, 2163-75 (2012). 22780989
Schmidt, D. et al. A CTCF-independent role for cohesin in tissue-specific transcription. Genome Res. 20, 578-88 (2010). 20219941 |
Protein Accession # |
NP_000448 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000457 |
Tested Species Reactivity |
Human, Rat |
Gene Symbol |
HNF4A |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 93% |
Image 1 | Human Lung Tumor
| Host: Rabbit Target Name: HNF4A Sample Tissue: Human Lung Tumor Antibody Dilution: 1.0ug/ml |
|
Image 2 | Rat Skeletal Muscle
| Host: Rat Target Name: HNF4A Sample Tissue: Rat Skeletal Muscle Antibody Dilution: 1ug/ml |
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