Product Number |
ARP31939_P050 |
Product Page |
www.avivasysbio.com/hmgb2-antibody-c-terminal-region-arp31939-p050.html |
Name |
HMGB2 Antibody - C-terminal region (ARP31939_P050) |
Protein Size (# AA) |
209 amino acids |
Molecular Weight |
24kDa |
NCBI Gene Id |
3148 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
High mobility group box 2 |
Alias Symbols |
HMG2 |
Peptide Sequence |
Synthetic peptide located within the following region: AAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Melvin,V.S., et al., (2004) J. Biol. Chem. 279 (15), 14763-14771 |
Description of Target |
This protein is a member of the non-histone chromosomal high mobility group family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in the DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Protein Interactions |
PKNOX1; UBC; EED; YWHAG; PGD; LDHB; CKB; HMGA1; GZMK; GZMA; CSNK1A1; FN1; SCAF8; APP; TFAP4; CDK2; BKRF1; Cebpb; ELAVL1; HMGB1; CHAF1A; CREBBP; SET; PGR; POU3F1; PRKDC; TP53; RAG1; POU5F1; POU2F2; POU2F1; APEX1; AR; NR3C1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-HMGB2 (ARP31939_P050) antibody |
Blocking Peptide |
For anti-HMGB2 (ARP31939_P050) antibody is Catalog # AAP31939 (Previous Catalog # AAPP02836) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human HMGB2 |
Uniprot ID |
P26583 |
Protein Name |
High mobility group protein B2 |
Sample Type Confirmation |
HMGB2 is supported by BioGPS gene expression data to be expressed in Jurkat |
Protein Accession # |
NP_002120 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_002129 |
Tested Species Reactivity |
Human |
Gene Symbol |
HMGB2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85% |
Image 1 | Human Liver
| Human Liver |
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Image 2 | Human Lung
| Human Lung |
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Image 3 | Human Jurkat
| WB Suggested Anti-HMGB2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysateHMGB2 is supported by BioGPS gene expression data to be expressed in Jurkat |
|
Image 4 | Human Heart
| Rabbit Anti-HMGB2 antibody Catalog Number: ARP31939 Paraffin Embedded Tissue: Human Heart cell Cellular Data: cardiac cell of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X |
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