HMGB2 Antibody - C-terminal region (ARP31939_P050)

Data Sheet
 
Product Number ARP31939_P050
Product Page www.avivasysbio.com/hmgb2-antibody-c-terminal-region-arp31939-p050.html
Name HMGB2 Antibody - C-terminal region (ARP31939_P050)
Protein Size (# AA) 209 amino acids
Molecular Weight 24kDa
NCBI Gene Id 3148
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name High mobility group box 2
Alias Symbols HMG2
Peptide Sequence Synthetic peptide located within the following region: AAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Melvin,V.S., et al., (2004) J. Biol. Chem. 279 (15), 14763-14771
Description of Target This protein is a member of the non-histone chromosomal high mobility group family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in the DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interactions PKNOX1; UBC; EED; YWHAG; PGD; LDHB; CKB; HMGA1; GZMK; GZMA; CSNK1A1; FN1; SCAF8; APP; TFAP4; CDK2; BKRF1; Cebpb; ELAVL1; HMGB1; CHAF1A; CREBBP; SET; PGR; POU3F1; PRKDC; TP53; RAG1; POU5F1; POU2F2; POU2F1; APEX1; AR; NR3C1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-HMGB2 (ARP31939_P050) antibody
Blocking Peptide For anti-HMGB2 (ARP31939_P050) antibody is Catalog # AAP31939 (Previous Catalog # AAPP02836)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human HMGB2
Uniprot ID P26583
Protein Name High mobility group protein B2
Sample Type Confirmation

HMGB2 is supported by BioGPS gene expression data to be expressed in Jurkat

Protein Accession # NP_002120
Purification Affinity Purified
Nucleotide Accession # NM_002129
Tested Species Reactivity Human
Gene Symbol HMGB2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Image 1
Human Liver
Human Liver
Image 2
Human Lung
Human Lung
Image 3
Human Jurkat
WB Suggested Anti-HMGB2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysateHMGB2 is supported by BioGPS gene expression data to be expressed in Jurkat
Image 4
Human Heart
Rabbit Anti-HMGB2 antibody
Catalog Number: ARP31939
Paraffin Embedded Tissue: Human Heart cell Cellular Data: cardiac cell of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
 

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