| Product Number |
ARP31652_P050 |
| Product Page |
www.avivasysbio.com/esr2-antibody-n-terminal-region-arp31652-p050.html |
| Name |
ESR2 Antibody - N-terminal region (ARP31652_P050) |
| Protein Size (# AA) |
530 amino acids |
| Molecular Weight |
59kDa |
| NCBI Gene Id |
2100 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Estrogen receptor 2 (ER beta) |
| Alias Symbols |
Erb, ESRB, ODG8, ESTRB, NR3A2, ER-BETA, ESR-BETA |
| Peptide Sequence |
Synthetic peptide located within the following region: TPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGN |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Rothwarf,D.M., et al., (2006) J. Endocrinol. Invest. 29 (1), 5-10 |
| Description of Target |
ESR2 is a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. |
| Protein Interactions |
PLSCR1; MEOX2; NOTCH2NL; RFX6; MMS19; BCAS2; NCOA1; RPS18; MRPS15; MRPS22; ZC3HAV1; PTCD3; EXOSC4; MRPS2; MED4; MRPS27; MRPS31; MED17; TRIM24; NRIP1; NCOA3; STAU1; SP1; PABPC5; MYLK2; RPS11; RPS4X; RPLP0; RPL36AL; PPP5C; HSPA8; ESR2; ESR1; ACTB; SRA1; ARI |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ESR2 (ARP31652_P050) antibody |
| Specificity |
Directed towards isoforms 1-8. |
| Blocking Peptide |
For anti-ESR2 (ARP31652_P050) antibody is Catalog # AAP31652 (Previous Catalog # AAPP02439) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ESR2 |
| Uniprot ID |
Q92731 |
| Protein Name |
Estrogen receptor beta |
| Sample Type Confirmation |
There is BioGPS gene expression data showing that ESR2 is expressed in HepG2 |
| Protein Accession # |
NP_001428 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001437 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ESR2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Sheep |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 93%; Goat: 93%; Guinea Pig: 93%; Horse: 79%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 85%; Rat: 100%; Sheep: 93% |
| Image 1 | Human HepG2
 | WB Suggested Anti-ESR2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that ESR2 is expressed in HepG2 |
|
| Image 2 | Human liver
 | WB Suggested Anti-ESR2 antibody Titration: 1 ug/mL
Sample Type: Human liver |
|
