| Product Number |
ARP31459_T100 |
| Product Page |
www.avivasysbio.com/yaf2-antibody-middle-region-arp31459-t100.html |
| Name |
YAF2 Antibody - middle region (ARP31459_T100) |
| Protein Size (# AA) |
180 amino acids |
| Molecular Weight |
20kDa |
| NCBI Gene Id |
10138 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
YY1 associated factor 2 |
| Alias Symbols |
MGC41856 |
| Peptide Sequence |
Synthetic peptide located within the following region: KGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKK |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Madge,B., (2003) Cancer Lett. 193 (2), 171-176 |
| Description of Target |
YAF2 interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. YAF2 contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two have been confirmed to date. |
| Protein Interactions |
SETBP1; XAGE1E; RING1; RNF2; BMI1; GABPB1; CSNK2A2; UBC; CAND1; PCGF1; KDM2B; PCGF5; PCGF6; L3MBTL2; FBRS; BCORL1; BCOR; MGA; CBX3; WDR5; PCGF3; YAF2; USP7; PCGF2; TFDP1; SKP1; HDAC2; E2F6; CSNK2A1; ZFP42; YY1; MYCN; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-YAF2 (ARP31459_T100) antibody |
| Blocking Peptide |
For anti-YAF2 (ARP31459_T100) antibody is Catalog # AAP31459 (Previous Catalog # AAPP24060) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human YAF2 |
| Uniprot ID |
Q8IY57 |
| Protein Name |
YY1-associated factor 2 |
| Protein Accession # |
NP_005739 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_005748 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
YAF2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-YAF2 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate |
| | Image 2 | Human Muscle
 | HumanMuscle |
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