CCBP2 Antibody - N-terminal region (ARP30776_P050)

• Product Number: ARP30776_P050
• Name: CCBP2 Antibody - N-terminal region (ARP30776_P050)
• Protein Size (# AA): 384 amino acids
• Molecular Weight: 43kDa
• NCBI Gene Id: 1238
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Chemokine binding protein 2
• Alias Symbols: D6, hD6, CCR9, CCBP2, CCR10, CMKBR9
• Peptide Sequence: Synthetic peptide located within the following region: MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLP
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Galliera,E., (2004) J. Biol. Chem. 279 (24), 25590-25597
• Description of Target: CCBP2 is a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown.This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
• Protein Interactions: APP; CCL3L3; CCL28; CCL27; CCL21; CCL25; CCL8; CCL19; CCL14; CCL13; CCL11; CCL5; CCL4; CCL3; CCL7; CCL2;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-ACKR2 (ARP30776_P050) antibody is Catalog # AAP30776 (Previous Catalog # AAPP24009)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CCBP2
• Uniprot ID: O00590
• Protein Name: Chemokine-binding protein 2
• Protein Accession #: NP_001287
• Purification: Affinity Purified
• Nucleotide Accession #: NM_001296
• Tested Species Reactivity: Human
• Gene Symbol: ACKR2
• Predicted Species Reactivity: Human, Rabbit
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Rabbit: 86%
• Image 1: Human Muscle
  
  Human Muscle
• Image 2: Human Jurkat
  
  WB Suggested Anti-CCBP2 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:62500
  Positive Control: Jurkat cell lysate