| Product Number |
ARP30416_P050 |
| Product Page |
www.avivasysbio.com/crk-antibody-c-terminal-region-arp30416-p050.html |
| Name |
CRK Antibody - C-terminal region (ARP30416_P050) |
| Protein Size (# AA) |
304 amino acids |
| Molecular Weight |
34kDa |
| NCBI Gene Id |
1398 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
V-crk sarcoma virus CT10 oncogene homolog (avian) |
| Alias Symbols |
p38, CRKII |
| Peptide Sequence |
Synthetic peptide located within the following region: IPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
| Protein Interactions |
FAM154A; HUWE1; ABL2; ABL1; SPRR2A; MET; CBL; BAG3; LMNA; ERBB3; ERBB2; EGFR; PPFIBP2; ATXN1; PTPN4; MAPK4; DOK1; BCAR1; NANS; FUBP1; SPR; HSPB1; DHX9; SERPINH1; ATIC; PIK3R2; PIK3R1; PIK3CD; PIK3CB; PIK3CA; PIK3C2B; SERPINB6; LYZ; KRT19; KRT17; KRT16; KR |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CRK (ARP30416_P050) antibody |
| Blocking Peptide |
For anti-CRK (ARP30416_P050) antibody is Catalog # AAP30416 |
| Uniprot ID |
P46108 |
| Protein Name |
Adapter molecule crk |
| Protein Accession # |
NP_058431 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_016823 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CRK |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100% |
| Image 1 | Transfected 293T
 | WB Suggested Anti-CRK Antibody
Titration: 1.0 ug/ml
Positive Control: Transfected 293T |
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