Product Number |
ARP30325_P050 |
Product Page |
www.avivasysbio.com/bad-antibody-c-terminal-region-arp30325-p050.html |
Name |
BAD Antibody - C-terminal region (ARP30325_P050) |
Protein Size (# AA) |
168 amino acids |
Molecular Weight |
18kDa |
NCBI Gene Id |
572 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
BCL2-associated agonist of cell death |
Alias Symbols |
BBC2, BCL2L8 |
Peptide Sequence |
Synthetic peptide located within the following region: RMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSA |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Xia,L., (2008) Int. J. Cancer 123 (2), 372-379 |
Description of Target |
BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
Protein Interactions |
BCL2L1; BCL2; AKT1; PAK1; BMH1; YWHAB; SFN; YWHAZ; RAF1; PRKACA; BRAF; ARAF; CREB3L3; STEAP3; YWHAQ; KEAP1; YWHAH; YWHAE; PRDX2; CDKN1A; VCP; SNCA; PPP1CA; BAX; SUMO2; YWHAG; PIM3; MCL1; RPS6KA5; PAK7; BCL2L10; WASF1; HRK; MAP2K5; BCL2L2; RPS6KA2; RPS6KA1 |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-BAD (ARP30325_P050) antibody |
Blocking Peptide |
For anti-BAD (ARP30325_P050) antibody is Catalog # AAP30325 (Previous Catalog # AAPP00706) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human BAD |
Uniprot ID |
Q92934 |
Protein Name |
Bcl2 antagonist of cell death |
Protein Accession # |
NP_004313 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_004322 |
Tested Species Reactivity |
Human |
Gene Symbol |
BAD |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 90%; Guinea Pig: 100%; Horse: 90%; Human: 100%; Mouse: 100%; Pig: 90%; Rabbit: 100%; Rat: 100% |
Image 1 | Human Liver
| WB Suggested Anti-BAD Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Liver |
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