BAD Antibody - C-terminal region (ARP30325_P050)

Data Sheet
 
Product Number ARP30325_P050
Product Page www.avivasysbio.com/bad-antibody-c-terminal-region-arp30325-p050.html
Name BAD Antibody - C-terminal region (ARP30325_P050)
Protein Size (# AA) 168 amino acids
Molecular Weight 18kDa
NCBI Gene Id 572
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name BCL2-associated agonist of cell death
Alias Symbols BBC2, BCL2L8
Peptide Sequence Synthetic peptide located within the following region: RMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSA
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Xia,L., (2008) Int. J. Cancer 123 (2), 372-379
Description of Target BAD is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Protein Interactions BCL2L1; BCL2; AKT1; PAK1; BMH1; YWHAB; SFN; YWHAZ; RAF1; PRKACA; BRAF; ARAF; CREB3L3; STEAP3; YWHAQ; KEAP1; YWHAH; YWHAE; PRDX2; CDKN1A; VCP; SNCA; PPP1CA; BAX; SUMO2; YWHAG; PIM3; MCL1; RPS6KA5; PAK7; BCL2L10; WASF1; HRK; MAP2K5; BCL2L2; RPS6KA2; RPS6KA1
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-BAD (ARP30325_P050) antibody
Blocking Peptide For anti-BAD (ARP30325_P050) antibody is Catalog # AAP30325 (Previous Catalog # AAPP00706)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human BAD
Uniprot ID Q92934
Protein Name Bcl2 antagonist of cell death
Protein Accession # NP_004313
Purification Affinity Purified
Nucleotide Accession # NM_004322
Tested Species Reactivity Human
Gene Symbol BAD
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 90%; Guinea Pig: 100%; Horse: 90%; Human: 100%; Mouse: 100%; Pig: 90%; Rabbit: 100%; Rat: 100%
Image 1
Human Liver
WB Suggested Anti-BAD Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Liver
 

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