C2 Peptide - N-terminal region (AAP41668)

Data Sheet
 
Sku AAP41668
Old sku AAPP10801
Price $99.00
Name C2 Peptide - N-terminal region (AAP41668)
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Size 100 ug
Gene C2
Alias symbols CO2, ARMD14
Gene id 717
Description of target Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Swissprot id P06681
Protein accession num NP_000054
Nucleotide accession num NM_000063
Protein size 752 amino acids
Molecular weight 81kDa
Application WB
Partner proteins PSMA4; MASP1; C5; C3; C4B;
Quality control The peptide is characterized by mass spectroscopy
Key reference Lee,K.Y., (2008) Invest. Ophthalmol. Vis. Sci. 49 (6), 2613-2619
Description This is a synthetic peptide designed for use in combination with anti-C2 antibody (Catalog #: ARP41668_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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