Sku |
AAP38212 |
Old sku |
AAPP20388 |
Price |
$99.00 |
Name |
SIAH1 Peptide (AAP38212) |
Purchase info |
To purchase this peptide:
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|
Size |
100 ug |
Gene |
SIAH1 |
Alias symbols |
SIAH1A |
Gene id |
6477 |
Description of target |
SIAH1 is a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterizedThis gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
Swissprot id |
Q8IUQ4 |
Protein accession num |
NP_003022 |
Nucleotide accession num |
NM_003031 |
Protein size |
282 amino acids |
Molecular weight |
31kDa |
Application |
IHC, WB |
Partner proteins |
DCC,DCC,UBE2I,UBE2I,AFF1,AFF4,APC,ATN1,BAG1,CACYBP,DAB1,DCC,EIF3J,GAPDH,HIPK3,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PKD1,POU2AF1,RBBP8,SH3RF1,SIAH1,SLC9A3R2,SNCAIP,SYP,TUBA1A,TUBA1B,TUBA3C,TUBA4A,TUBA8,UBE2D1,AFF4,APC,BAG1,CACYBP,DAB1,DCC,HIF1AN,KHDRBS3,KIF22,NUMB,PEG10,PEG3,PIAS1,PIAS2,PIAS3,POU2AF1,RBBP8,SIAH1,SYP,TBL1X,TRIB3,UBE2D1,UBE2E3,UBE2I,VAV1 |
Quality control |
The peptide is characterized by mass spectroscopy |
Key reference |
Avraham,E., et al., (2005) J. Biol. Chem. 280 (52), 42877-42886 |
Description |
This is a synthetic peptide designed for use in combination with anti-SIAH1 antibody (Catalog #: ARP38212_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
Product format |
Lyophilized powder |
Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
Protocol |
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Tips |
See our General FAQ page. |
Availability |
In Stock |