| Sku |
AAP33450 |
| Old sku |
AAPP04496 |
| Price |
$99.00 |
| Name |
RAD51 Peptide - N-terminal region (AAP33450) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
RAD51 |
| Alias symbols |
BRCC5, HRAD51, HsRad51, HsT16930, RAD51A, RECA |
| Gene id |
5888 |
| Description of target |
RAD51 is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. |
| Swissprot id |
Q06609-2 |
| Protein accession num |
NP_597994 |
| Nucleotide accession num |
NM_133487 |
| Protein size |
242 amino acids |
| Molecular weight |
26kDa |
| Application |
IHC, WB |
| Partner proteins |
E2F1,E2F4,BLM,BRCA1,BRCA2,BRCA1,BRCA2,ABL1,ATM,ATRX,BCCIP,BLM,BRCA1,BRCA2,C17orf28,CASP3,CASP7,CHD3,CHEK1,DMC1,DNAJA3,ERCC2,FANCD2,IRS1,RAD51,RAD51AP1,RAD51AP2,RAD51C,RAD52,RAD54B,RAD54L,RPA1,SUMO1,TP53,UBE2I,VIM,ABL1,ATM,ATRAD51,ATRX,BARD1,BLM,BRCA1,BRCA2,BRCA2,BRCA2(IV),BRCC3,BRE,CAB39,CHD3,CHEK1,DMC1,DNAJA3,H2AFX,LGTN,MCPH1,MSH4,RAD18,RAD51,RAD51AP1,RAD51C,RAD51L1,RAD51L3,RAD52,RAD54B,RPA1,SUMO1,TIMM13,TP53,UBE2I,VIM,XRCC2,XRCC3,tax |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Park,J.Y., (2008) Nucleic Acids Res. 36 (10), 3226-3234 |
| Description |
This is a synthetic peptide designed for use in combination with anti-RAD51 antibody (Catalog #: ARP33450_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
|
