| Sku |
AAP32557 |
| Old sku |
AAPP32106 |
| Price |
$99.00 |
| Name |
GFI1 Peptide (AAP32557) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
GFI1 |
| Alias symbols |
ZNF163, SCN2, GFI-1 |
| Gene id |
2672 |
| Description of target |
GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. |
| Swissprot id |
Q99684 |
| Protein accession num |
NP_005254 |
| Nucleotide accession num |
NM_005263 |
| Protein size |
422 amino acids |
| Molecular weight |
45kDa |
| Application |
WB |
| Partner proteins |
PIAS3,PICK1,RUNX1T1,ARIH2,PIAS3,RUNX1T1,UBC |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Doan,L.L., et al., (2004) Nucleic Acids Res. 32 (8), 2508-2519 |
| Description |
This is a synthetic peptide designed for use in combination with anti-GFI1 antibody (Catalog #: ARP32557_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
