| Sku |
AAP31753 |
| Old sku |
AAPP23838 |
| Price |
$99.00 |
| Name |
TLR5 Peptide - N-terminal region (AAP31753) |
| Purchase info |
To purchase this peptide:
- Copy peptide sku
- Click on this link
- Paste into field "Peptide Sku"
|
| Size |
100 ug |
| Gene |
TLR5 |
| Alias symbols |
FLJ10052, MGC126430, MGC126431, SLEB1, TIL3 |
| Gene id |
7100 |
| Description of target |
TLR5 participates in the innate immune response to microbial agents. It mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Swissprot id |
O60602 |
| Protein accession num |
NP_003259 |
| Nucleotide accession num |
NM_003268 |
| Protein size |
858 amino acids |
| Molecular weight |
98kDa |
| Application |
WB |
| Partner proteins |
MYD88,RNF216,SIGIRR,TLR1,TLR4,MYD88,RNF216 |
| Quality control |
The peptide is characterized by mass spectroscopy |
| Key reference |
Hume,G.E., (2008) Inflamm. Bowel Dis. 14 (5), 585-590 |
| Description |
This is a synthetic peptide designed for use in combination with anti-TLR5 antibody (Catalog #: ARP31753_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details. |
| Product format |
Lyophilized powder |
| Reconstitution and storage |
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles. |
| Lead time |
Domestic: within 24 hours delivery International: 3-5 business days |
| Protocol |
|
| Tips |
See our General FAQ page. |
| Availability |
In Stock |
