TRAF6 Peptide - middle region (AAP30226)

Data Sheet
 
Sku AAP30226
Old sku AAPS09104
Price $99.00
Name TRAF6 Peptide - middle region (AAP30226)
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Size 100 ug
Gene TRAF6
Alias symbols MGC:3310, RNF85
Gene id 7189
Description of target TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein.The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
Swissprot id Q9Y4K3
Protein accession num NP_004611
Nucleotide accession num NM_004620
Protein size 522 amino acids
Molecular weight 59kDa
Application WB
Partner proteins IRAK1,IRAK2,IRAK3,IRF7,MALT1,MAP3K14,TAB3,TICAM1,TICAM1,TICAM2,TRAF6,UBB,UBB,ZFAND5,ABL1,ATP6V1E1,CAV1,CBL,CD40,CYLD,ECSIT,EDA2R,FHL2,HSPA4,IL17RB,IRAK1,IRAK2,IRAK3,IRAK4,IRF5,IRF7,IRF8,KCNQ1,MALT1,MAP2K1,MAP2K6,MAP2K7,MAP3K14,MAP3K3,MAP3K5,MAP3K7,MAP3K8,MAPK14,MAPK8,MAST2,MAVS,MBP,NGFR,NGFRAP1,OTUD7B,PELI3,PRKCZ,PSMB5,PSMC1,PSMC2,PSMC3,PSMD1,PSMD12,PSMD13,PSMD6,PSMD7,PTPN6,RIPK2,SIGIRR,SPHK1,SQSTM1,SRC,STRADB,SYK,TAB1,TAB2,TAB3,TAX1BP1,TDP2,TICAM1,TICAM2,TIFA,TIRAP,TLR3,TMEM189-UBE2V1,TNFAIP3,TNFRSF11A,TNFRSF13B,TNFRSF19,TNFSF11,TRAF2,TRAF3IP2,TRAF4,TRAF6,TRAF7,TRAFD1,TRAM1,TRIM37,UBB,UBE2N,USP7,XIAP,ZFAND5,ZMYND11,ZNF675,ZRANB1,ASXL2,BMPR1B,CD40,CTPS,DDX3X,EDA2R,EIF4E2,EPPK1,Ecsit,FHL2,GANAB,HSPB2,IARS,IKBKG,IL17RA,IRAK1,IRAK2,IRAK3,IRAK4,KCNQ1,MAP3K14,MAP3K5,MAP3K7,MAST2,MCM7,MTHFD1,MYD88,Map3k7,NASP,NGFR,NTRK1,NTRK2,OTUD7B,PAICS,PELI3,PFAS,PPP4C,PRKCZ,PSEN1,PSMB5,PSMC1,PSMC2,PSMC3,PSMD1,PSMD12,PSMD13,PSMD3,PSMD7,RIPK2,RUNX1,SDCBP,SIGIRR,SPOP,SQSTM1,SRC,STRADB,SYK,TAB1,TAB2,TAB3,TARS,TAX1BP1,TDP2,TGFBR1,TIFA,TIRAP,TJP2,TNFAIP3,TNFRSF11A,TNFRSF13B,TRAF2,TRAF3IP1,TRAF6,TRIM37,UBC,UBE2N,UBE2V1,USP7,VARS,VCP,VDAC1,XIAP,ZFAND5,ZMYND11,ZNF675,ZRANB1
Quality control The peptide is characterized by mass spectroscopy
Key reference Jazdzewski,K., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (20), 7269-7274
Description This is a synthetic peptide designed for use in combination with anti-TRAF6 antibody (Catalog #: ARP30226_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Product format Lyophilized powder
Reconstitution and storage Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Lead time Domestic: within 24 hours delivery  International: 3-5 business days
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