Apoptosis pathway Fas-L TRAIL IL-1 TNFR1 TRAIL-R FADD FADD FADD TRADD MyD88 IRAK PI3K NIK FLIP IKK Akt/PKB PKA Cn Bcl-2/XL IkBa NF-KB CASP3 Bad Bad RIP1 TRADD TRADD DFF45 DFF40 Bcl-XL Bcl-2 Bax CASP3 AIF ENDO-G P53