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Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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Showing 91 - 95 of 95
  • TRIAL 
    JUN antibody - N-terminal region (P100911_P050) in Human HEK293T using Western Blot
    Human Lung
    JUN antibody - N-terminal region (P100911_P050) in HCT116 using Chromatin Immunoprecitation

    JUN antibody - N-terminal region (P100911_P050)

    Protein Name:Transcription factor AP-1
    Catalog #:P100911_P050
    Type: pAb
    Reacts with: Cow, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep
    Application: CHIP, IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    WNT5A antibody - middle region (ARP32128_P050) in Human HeLa using Western Blot
    WNT5A antibody - middle region (ARP32128_P050) in Human Placenta using Immunohistochemistry
    WNT5A antibody - middle region (ARP32128_P050) in Human Colon using Immunohistochemistry
    WNT5A antibody - middle region (ARP32128_P050) in Human Brain using Immunohistochemistry

    WNT5A antibody - middle region (ARP32128_P050)

    Protein Name:Protein Wnt-5a
    Catalog #:ARP32128_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    RAC1 antibody - middle region (ARP57798_P050) in Human HepG2 using Western Blot
    RAC1 antibody - middle region (ARP57798_P050) in siRUVBL1 transfected human H1299 using Western Blot

    RAC1 antibody - middle region (ARP57798_P050)

    Protein Name:Ras-related C3 botulinum toxin substrate 3
    Catalog #:ARP57798_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CHP antibody - N-terminal region (ARP52307_P050) in Human 721_B using Western Blot
    CHP antibody - N-terminal region (ARP52307_P050) in Human Adult Liver using Immunohistochemistry

    CHP antibody - N-terminal region (ARP52307_P050)

    Protein Name:Calcineurin B homologous protein 1
    Catalog #:ARP52307_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    CTBP2 antibody - C-terminal region (ARP50670_P050) in Human HeLa using Western Blot
    CTBP2 antibody - C-terminal region (ARP50670_P050) in Hum. Fetal Brain using Western Blot
    CTBP2 antibody - C-terminal region (ARP50670_P050) in Hum. Adult Placenta using Western Blot
    CTBP2 antibody - C-terminal region (ARP50670_P050) in Mouse retina using Immunohistochemistry

    CTBP2 antibody - C-terminal region (ARP50670_P050)

    Protein Name:C-terminal-binding protein 2
    Catalog #:ARP50670_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00

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Showing 91 - 95 of 95