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Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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Showing 61 - 78 of 78
  Type Catalog # Product Product Images Price (USD)
  pAb OASA07105 Camk2a Antibody (OASA07105)
Reacts with
Human
Application
ELISA, IF, IHC-FFPE, WB
$675.00
  pAb OASA07131 CTNNB1 Antibody (OASA07131)
Reacts with
Human
Application
IHC-AFF, ELISA, WB, IP, IHC-FFPE
$835.00
  pAb OASA07187 CTBP1 Antibody (OASA07187)
Reacts with
Human
Application
IF, IP, WB
$410.00
  pAb OASA07260 FZD7 antibody - C-terminal region (OASA07260)
Reacts with
Human
Application
IHC-FFPE
$720.00
  pAb OASA07320 Gsk3b Antibody (OASA07320)
Reacts with
Rat
Application
WB
$750.00
  pAb OASA07503 CSNK2A1 Antibody (OASA07503)
Reacts with
Human
Application
WB
$425.00
  pAb OASA07643 CREBBP Antibody (OASA07643)
Reacts with
Human
Application
IP, WB
$640.00
  pAb OASA07692 DKK1 Antibody (OASA07692)
Reacts with
Human
Application
IHC-FFPE
$750.00
  pAb OASA08061 EP300 Antibody (OASA08061)
Reacts with
Human
Application
IP, WB
$640.00
  pAb OASA08277 WNT1 Antibody (OASA08277)
Reacts with
Human
Application
ELISA, WB
$555.00
  pAb OASA08597 Ppard Antibody (OASA08597)
Reacts with
Mouse
Application
ELISA, IHC-FFPE, WB
$725.00
  pAb OASA08759 SFRP1 Antibody (OASA08759)
Reacts with
Human
Application
ELISA, IHC-FFPE, WB
$690.00
  pAb OASA08793 SMAD3 Antibody (OASA08793)
Reacts with
Human
Application
ELISA, IHC-FFPE, WB
$750.00
  pAb OASA08917 WNT2B Antibody (OASA08917)
Reacts with
Human
Application
IHC-FFPE
$750.00
  pAb P100890_P050 TCF7 antibody - C-terminal region (P100890_P050)
Reacts with
Dog, Human, Mouse, Rat
Application
WB
$289.00
  pAb P100911_P050 JUN antibody - N-terminal region (P100911_P050)
Reacts with
Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep
Application
CHIP, WB
$289.00
  pAb P100975_P050 NFATC3 antibody - N-terminal region (P100975_P050)
Reacts with
Bovine, Dog, Horse, Human, Mouse, Rat
Application
IHC, WB
$289.00
  pAb P100981_P050 NFATC1 antibody - N-terminal region (P100981_P050)
Reacts with
Dog, Guinea pig, Human, Mouse
Application
WB
$289.00

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