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Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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Showing 61 - 78 of 78
  Type Catalog # Product Product Images Price (USD)
  pAb ARP53596_P050 CSNK2A2 antibody - C-terminal region (ARP53596_P050)
Reacts with
Bovine, Dog, Pig, Horse, Rabbit, Human, Guinea pig, Yeast, Rat, Mouse
Application
WB
$289.00
  pAb ARP52809_P050 CSNK1A1L antibody - middle region (ARP52809_P050)
Reacts with
Human, Zebrafish, Rat, Mouse, Dog, Pig, Horse, Guinea pig
Application
WB
$289.00
  pAb ARP41283_P050 FZD8 antibody - N-terminal region (ARP41283_P050)
Reacts with
Dog, Human, Mouse, Rat
Application
WB
$289.00
  pAb ARP38493_P050 NFATC4 antibody - N-terminal region (ARP38493_P050)
Reacts with
Bovine, Human, Rat, Dog, Pig, Horse, Rabbit, Guinea pig, Mouse
Application
IHC, WB
$289.00
  pAb ARP57917_P050 TCF7L1 antibody - N-terminal region (ARP57917_P050)
Reacts with
Human, Mouse, Rat, Bovine, Dog, Rabbit
Application
WB
$289.00
  pAb ARP32101_T100 DVL1 antibody - C-terminal region (ARP32101_T100)
Reacts with
Human, Pig, Bovine, Rat, Dog, Horse, Mouse, Yeast, Guinea pig
Application
WB
$229.00
  pAb ARP55844_P050 PLCB1 antibody - middle region (ARP55844_P050)
Reacts with
Dog, Pig, Mouse, Rat, Guinea pig, Human, Bovine, Horse, Rabbit
Application
WB
$289.00
  pAb ARP52298_P050 WIF1 antibody - N-terminal region (ARP52298_P050)
Reacts with
Human, Bovine, Horse, Rabbit, Rat, Guinea pig, Mouse, Dog, Zebrafish
Application
WB
$289.00
  pAb ARP51259_T100 CACYBP antibody - middle region (ARP51259_T100)
Reacts with
Pig, Horse, Rabbit, Dog, Bovine, Human, Rat, Guinea pig, Mouse
Application
WB
$229.00
  pAb ARP32128_P050 WNT5A antibody - middle region (ARP32128_P050)
Reacts with
Human, Bovine, Rat, Rabbit, Guinea pig, Dog, Mouse, Horse, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP57798_P050 RAC1 antibody - middle region (ARP57798_P050)
Reacts with
Mouse, Zebrafish, Human, Bovine, Sheep, Dog, Horse, Rabbit, Rat, Guinea pig
Application
WB
$289.00
  pAb ARP52307_P050 CHP antibody - N-terminal region (ARP52307_P050)
Reacts with
Mouse, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Bovine, Zebrafish
Application
IHC, WB
$289.00
  pAb ARP50670_P050 CTBP2 antibody - C-terminal region (ARP50670_P050)
Reacts with
Dog, Bovine, Pig, Rabbit, Mouse, Rat, Guinea pig, Human, Horse, Goat
Application
IHC, WB
$289.00
  pAb ARP39552_P050 SOX17 antibody - middle region (ARP39552_P050)
Reacts with
Human, Pig, Guinea pig, Dog, Rat, Mouse
Application
IHC, WB
$289.00
  pAb ARP32349_P050 RUVBL1 antibody - N-terminal region (ARP32349_P050)
Reacts with
Bovine, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish, Goat
Application
WB
$289.00
  pAb ARP49762_P050 PORCN antibody - N-terminal region (ARP49762_P050)
Reacts with
Bovine, Rat, Human, Dog, Horse, Rabbit, Guinea pig, Mouse
Application
IHC, WB
$289.00
  pAb ARP41243_T100 WNT9B antibody - C-terminal region (ARP41243_T100)
Reacts with
Human
Application
IHC, WB
$229.00
  pAb P100911_P050 JUN antibody - N-terminal region (P100911_P050)
Reacts with
Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep
Application
CHIP, IHC, WB
$289.00

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Showing 61 - 78 of 78