Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.^[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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Type	Catalog #	Product	Product Images	Price (USD)
pAb	ARP52809_P050	CSNK1A1L antibody - middle region (ARP52809_P050) Reacts with Application WB	Human 721_B	$289.00
pAb	ARP53596_P050	CSNK2A2 antibody - C-terminal region (ARP53596_P050) Reacts with Bovine, Dog, Horse, Pig, Rabbit, Guinea pig, Mouse, Rat Application WB	Human HepG2	$289.00
pAb	ARP55131_P050	DAAM1 antibody - middle region (ARP55131_P050) Reacts with Bovine, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Dog, Chicken, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP55844_P050	PLCB1 antibody - middle region (ARP55844_P050) Reacts with Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Horse Application WB	Human HepG2	$289.00
pAb	ARP56124_P050	PPP3R1 antibody - N-terminal region (ARP56124_P050) Reacts with African clawed frog, Chicken, Human, Rabbit, Rat, Zebrafish Application WB	Human NCI-H226	$289.00
pAb	ARP56426_P050	PRKCG antibody - middle region (ARP56426_P050) Reacts with Bovine, Dog, Horse, Human, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP56626_P050	PRKX antibody - N-terminal region (ARP56626_P050) Reacts with Human Application WB	Human HepG2	$289.00
pAb	ARP56863_P050	NLK antibody - middle region (ARP56863_P050) Reacts with Bovine, Guinea pig, Horse, Human, Mouse, Rat, African clawed frog, Chicken, Dog, Rabbit, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP57516_P050	Ppp3cb antibody - C-terminal region (ARP57516_P050) Reacts with Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, African clawed frog, Zebrafish Application WB	Mouse Heart	$289.00
pAb	ARP57548_P050	SENP2 antibody - middle region (ARP57548_P050) Reacts with Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat Application WB	Human COLO205	$289.00
pAb	ARP57781_P050	PPP2R1B antibody - N-terminal region (ARP57781_P050) Reacts with Human, African clawed frog, Bovine, Dog, Guinea pig, Horse, Mouse, Rabbit, Rat, Zebrafish Application WB	Human Thymus	$289.00
pAb	ARP57798_P050	RAC1 antibody - middle region (ARP57798_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish Application WB	Human HepG2	$289.00
pAb	ARP57917_P050	TCF7L1 antibody - N-terminal region (ARP57917_P050) Reacts with Human, Mouse, Rabbit Application WB	Human 293T	$289.00
pAb	ARP61921_P050	TBL1XR1 antibody - C-terminal region (ARP61921_P050) Reacts with Bovine, Chicken, Dog, Guinea pig, Horse, Human, Rabbit, Rat, Zebrafish Application WB	Human Jurkat	$289.00
pAb	AVARP03042_T100	RBX1 antibody - middle region (AVARP03042_T100) Reacts with Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rat, Zebrafish Application WB		$229.00
pAb	AVARP03049_T100	CUL1 antibody - C-terminal region (AVARP03049_T100) Reacts with African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Zebrafish Application WB	Human Jurkat	$229.00
mAb	OASA00538	MYC Antibody (OASA00538) Reacts with Application IHC-AFF, ELISA, FC, IHC-FFPE, WB	c-myc tagged protein	$705.00
mAb	OASA00562	CCND1 Antibody (OASA00562) Reacts with Application IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB		$470.00
mAb	OASA00564	CCND2 Antibody (OASA00564) Reacts with Application IHC-AFF, IP, WB		$700.00
mAb	OASA02653	CCND3 Antibody (OASA02653) Reacts with Application IHC-AFF, IHC-FFPE, WB		$1,075.00
mAb	OASA03187	TP53 Antibody (OASA03187) Reacts with Application IHC-AFF, IP, IHC-FFPE, WB		$390.00
mAb	OASA03762	PRKCA Antibody (OASA03762) Reacts with Application IHC-AFF, WB		$390.00
mAb	OASA03763	PRKCB Antibody (OASA03763) Reacts with Application IHC-AFF		$435.00
pAb	OASA06098	FZD4 Antibody (OASA06098) Reacts with Application ELISA, WB		$505.00
pAb	OASA06330	LEF1 Antibody (OASA06330) Reacts with Application ELISA, WB		$505.00
pAb	OASA06335	LRP6 Antibody (OASA06335) Reacts with Application ELISA, IHC-FFPE		$645.00
pAb	OASA06336	SMAD2 Antibody (OASA06336) Reacts with Application WB		$655.00
pAb	OASA06351	MMP7 Antibody (OASA06351) Reacts with Application ELISA, WB		$505.00
pAb	OASA06400	PPP2R5B Antibody (OASA06400) Reacts with Application WB		$530.00
pAb	OASA06402	PPP2R5D Antibody (OASA06402) Reacts with Application WB		$520.00

Aviva Systems Biology

Wnt Signaling Pathway

Reacts with

Application

WB

Reacts with

Bovine, Dog, Horse, Pig, Rabbit, Guinea pig, Mouse, Rat

Application

WB

Reacts with

Bovine, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Dog, Chicken, Zebrafish

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Horse

Application

WB

Reacts with

African clawed frog, Chicken, Human, Rabbit, Rat, Zebrafish

Application

WB

Reacts with

Bovine, Dog, Horse, Human, Zebrafish

Application

WB

Reacts with

Human

Application

WB

Reacts with

Bovine, Guinea pig, Horse, Human, Mouse, Rat, African clawed frog, Chicken, Dog, Rabbit, Zebrafish

Application

WB

Reacts with

Bovine, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, African clawed frog, Zebrafish

Application

WB

Reacts with

Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat

Application

WB

Reacts with

Human, African clawed frog, Bovine, Dog, Guinea pig, Horse, Mouse, Rabbit, Rat, Zebrafish

Application

WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish

Application

WB

Reacts with

Human, Mouse, Rabbit

Application

WB

Reacts with

Bovine, Chicken, Dog, Guinea pig, Horse, Human, Rabbit, Rat, Zebrafish

Application

WB

Reacts with

Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rat, Zebrafish

Application

WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Zebrafish

Application

WB

Reacts with

Application

IHC-AFF, ELISA, FC, IHC-FFPE, WB

Reacts with

Application

IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB

Reacts with

Application

IHC-AFF, IP, WB

Reacts with

Application

IHC-AFF, IHC-FFPE, WB

Reacts with

Application

IHC-AFF, IP, IHC-FFPE, WB