website statistics

Aviva Systems Biology

Account Login 

Aviva's office will be closed on 4/18/2014 for Good Friday holiday. Please go here for more info.

Now Offering Over 85,203 Antibodies & 34,301 Antigens!

Print Page
50ug
$289.00
In Stock

RUVBL1 antibody - N-terminal region (ARP32349_P050)

Receive a free positive control (AHL003) when you purchase this antibody. Use the promotion code 'freecontrol' when placing your order.
Please go here for more details.
Description of Target:
RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Gene Symbol:
RUVBL1
Official Gene Full Name:
RuvB-like 1 (E. coli)
NCBI Gene Id:
8607
Alias Symbols:
ECP54; NMP238; Pontin52; RVB1; TIH1; TIP49; TIP49A; INO80H; PONTIN
Tissue Tool:
Find tissues and cell lines supported to express RUVBL1.
Protein Accession #:
NP_003698
Nucleotide Accession#:
NM_003707
Swissprot Id:
Q9Y265
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
RuvB-like 1
Protein Size (# AA):
456
Molecular Weight:
50kDa
Application:
WB
Partner Proteins:
ASCL1, BMP2, EP300, MEF2A, NEUROG2, TCF4, UBQLN1, EP300, MEF2A, TCF4
Immunogen:
The immunogen for anti-RUVBL1 antibody: synthetic peptide directed towards the N terminal of human RUVBL1
Product Format:
Lyophilized powder
Purification:
Affinity Purified
Complete computational species homology data:
RUVBL1 antibody - N-terminal region (ARP32349_P050)
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Zebrafish: 100%; Guinea pig: 100%; Goat: 77%
Species Reactivity:
Bovine, Human, Dog, Pig, Horse, Rabbit, Rat, Guinea pig, Mouse, Zebrafish, Goat
Datasheets / Downloads:
Printable datasheet for
anti-RUVBL1 antibody
- ARP32349_P050
Peptide Sequence:
Synthetic peptide located within the following region: KIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGV
Blocking Peptide:
For anti-RUVBL1 antibody is Catalog # AAP32349 (Previous Catalog # AAPP03338)
Key Reference:
Jha,S., (2008) Mol. Cell. Biol. 28 (8), 2690-2700
Reconstitution and Storage:
Add 50 ul of distilled water. Final anti-RUVBL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
 
X
Ask a Question