DVL1 antibody - C-terminal region (ARP32101_T100)

Catalog#: ARP32101_T100

• Size: 100ug

Human K562

• Description of Target: DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.
• Gene Symbol: DVL1
• Official Gene Full Name: Dishevelled, dsh homolog 1 (Drosophila)
• Alias Symbols: DVL; MGC54245; DVL1L1
• Protein Accession#: NP_004412
• Nucleotide Accession#: NM_004421
• Swissprot Id: O14640-2
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 670
• Molecular Weight: 73kDa
• Application: WB
• Partner Proteins: A2BP1, AP1M1, AP2M1, ARR3, ARRB1, ARRB2, ATN1, AXIN1, BAG3, BAHD1, C16orf48, C9orf100, CCDC33, CPSF7, CSNK1E, DAAM1, DDI1, DPPA2, DVL2, DYNLT1, FAM105B, FZD4, MCRS1, PCBD1, POLI, PPM1A, PRKCA, PRKCB, PRKCG, PRPF3, RAC1, RBPMS, RHOA, RHOXF2, RNPS1, RUNX2, SNF8, SNIP1, SORBS3, TCEB3B, THAP1, TIFA,
• Immunogen: The immunogen for anti-DVL1 antibody: synthetic peptide directed towards the C terminal of human DVL1
• Product Format: Lyophilized powder
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Pig: 92%; Bovine: 85%; Dog: 85%; Horse: 85%; Mouse: 85%; Rat: 85%
• Peptide Sequence: Synthetic peptide located within the following region: AAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPP
• Blocking Peptide: For anti-DVL1 antibody is Catalog # AAP32101 (Previous Catalog # AAPP03018)
• Key Reference: Mizutani,K., (2005) Am. J. Clin. Oncol. 91 (6), 546-551
• Reconstitution and Storage: Add 100 μl of distilled water. Final anti-DVL1 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: DVL1 antibody tested with Human K562 Cells (ARP32101_T100)

Aviva Systems Biology is the original manufacturer of this DVL1 antibody (ARP32101_T100)

Click here to view the DVL1 antibody Western Blot Protocol

Product Datasheet Link: DVL1 antibody (ARP32101_T100)

WB Suggested Anti-DVL1 Antibody Titration: 2.5ug/ml
Positive Control: K562

Western Blot image:


Description of Target: DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.

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Aviva Systems Biology’s DVL1 antibody (ARP32101_T100) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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