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Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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    WNT1 Antibody (OASA08277)

    WNT1 Antibody (OASA08277)

    Protein Name:Proto-oncogene Wnt-1
    Catalog #:OASA08277
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $555.00
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    WNT2B Antibody (OASA08917)

    WNT2B Antibody (OASA08917)

    Protein Name:Protein Wnt-2b
    Catalog #:OASA08917
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE
    Product Size: 50ug
    Price (USD): $750.00
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    WNT4 Antibody (OASA06495) in Human ovary and human testis using Western Blot

    WNT4 Antibody (OASA06495)

    Protein Name:Protein Wnt-4
    Catalog #:OASA06495
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
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    WNT16 antibody - C-terminal region (ARP41268_T100) in Human HepG2 using Western Blot

    WNT16 antibody - C-terminal region (ARP41268_T100)

    Protein Name:Protein Wnt-16
    Catalog #:ARP41268_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    WNT3 antibody - middle region (ARP49956_P050) in Human Brain using Western Blot

    WNT3 antibody - middle region (ARP49956_P050)

    Protein Name:Proto-oncogene Wnt-3
    Catalog #:ARP49956_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    WNT6 antibody - middle region (ARP46733_P050) in Human 293T using Western Blot

    WNT6 antibody - middle region (ARP46733_P050)

    Protein Name:Protein Wnt-6
    Catalog #:ARP46733_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    WIF1 antibody - N-terminal region (ARP52298_P050) in Human Muscle using Western Blot

    WIF1 antibody - N-terminal region (ARP52298_P050)

    Protein Name:Wnt inhibitory factor 1
    Catalog #:ARP52298_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    WNT5B antibody - C-terminal region (ARP41280_T100) in Human HepG2 using Western Blot

    WNT5B antibody - C-terminal region (ARP41280_T100)

    Protein Name:Protein Wnt-5b
    Catalog #:ARP41280_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    WNT2 antibody - middle region (ARP32124_P050) in Human THP-1 using Western Blot

    WNT2 antibody - middle region (ARP32124_P050)

    Protein Name:Protein Wnt-2
    Catalog #:ARP32124_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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