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Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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  • TRIAL 
    NFATC1 antibody - N-terminal region (P100981_P050) in Human Stomach using Western Blot
    NFATC1 antibody - N-terminal region (P100981_P050) in Human liver using Western Blot
    NFATC1 antibody - N-terminal region (P100981_P050) in liver using Immunohistochemistry.

    NFATC1 antibody - N-terminal region (P100981_P050)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 1
    Catalog #:P100981_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Human, Mouse
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Human 721_B using Western Blot
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Hum. Fetal Brain using Western Blot
    NFATC4 antibody - N-terminal region (ARP38493_P050) in Human Lung Tissue using Immunohistochemistry

    NFATC4 antibody - N-terminal region (ARP38493_P050)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 4
    Catalog #:ARP38493_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $289.00
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    NKD1 antibody - N-terminal region (ARP41285_P050) in Human HepG2 using Western Blot
    NKD1 antibody - N-terminal region (ARP41285_P050) in Human Lung using Immunohistochemistry

    NKD1 antibody - N-terminal region (ARP41285_P050)

    Protein Name:Protein naked cuticle homolog 1
    Catalog #:ARP41285_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    NFATC3 antibody - N-terminal region (P100975_P050) in Human HeLa using Western Blot
    NFATC3 antibody - N-terminal region (P100975_P050) in Human Fetal Lung using Western Blot
    NFATC3 antibody - N-terminal region (P100975_P050) in Human Thymus using Immunohistochemistry
    Human Lung

    NFATC3 antibody - N-terminal region (P100975_P050)

    Protein Name:Nuclear factor of activated T-cells c3 isoform IB-Xa EMBL ACG55625.1
    Catalog #:P100975_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
  •  
    NFATC2 antibody - N-terminal region (ARP37106_T100) in Mouse SP2/0 using Western Blot

    NFATC2 antibody - N-terminal region (ARP37106_T100)

    Protein Name:Nuclear factor of activated T-cells, cytoplasmic 2
    Catalog #:ARP37106_T100
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
  •  
    NFAT5 antibody - middle region (ARP38831_P050) in Human MCF-7 using Western Blot

    NFAT5 antibody - middle region (ARP38831_P050)

    Protein Name:Nuclear factor of activated T-cells 5
    Catalog #:ARP38831_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NKD2 antibody - N-terminal region (ARP41287_P050) in Human Jurkat using Western Blot

    NKD2 antibody - N-terminal region (ARP41287_P050)

    Protein Name:Protein naked cuticle homolog 2
    Catalog #:ARP41287_P050
    Type: pAb
    Reacts with: Horse, Human, Mouse, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
  • TRIAL 
    NLK antibody - middle region (ARP56863_P050) in Human 293T using Western Blot

    NLK antibody - middle region (ARP56863_P050)

    Protein Name:Serine/threonine-protein kinase NLK
    Catalog #:ARP56863_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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