Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.^[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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Type	Catalog #	Product	Product Images	Price (USD)
pAb	OASA07320	Gsk3b Antibody (OASA07320) Reacts with Application WB		$715.00
pAb	ARP37106_T100	NFATC2 antibody - N-terminal region (ARP37106_T100) Reacts with Mouse, Horse, Human, Rat, Bovine, Dog, Pig Application WB	Mouse SP2/0	$229.00
pAb	OASA08597	Ppard Antibody (OASA08597) Reacts with Application ELISA, IHC-FFPE, WB		$715.00
pAb	P100981_P050	NFATC1 antibody - N-terminal region (P100981_P050) Reacts with Human, Dog, Mouse, Guinea pig Application WB	Human Stomach	$289.00
pAb	ARP41287_P050	NKD2 antibody - N-terminal region (ARP41287_P050) Reacts with Human, Rat, Mouse Application WB	Human Jurkat	$289.00
pAb	ARP32349_P050	RUVBL1 antibody - N-terminal region (ARP32349_P050) Reacts with African clawed frog, Bovine, Dog, Horse, Human, Mouse, Rabbit, Zebrafish, Chicken Application WB	Human Heart	$289.00
pAb	AVARP03049_T100	CUL1 antibody - C-terminal region (AVARP03049_T100) Reacts with African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Zebrafish Application WB	Human Jurkat	$229.00
pAb	ARP51843_P050	CSNK1A1 antibody - C-terminal region (ARP51843_P050) Reacts with African clawed frog, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP51987_P050	CSNK1E antibody - N-terminal region (ARP51987_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Pig, Rat, Zebrafish Application WB	Human THP-1	$289.00
pAb	AVARP03042_T100	RBX1 antibody - middle region (AVARP03042_T100) Reacts with Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rat, Zebrafish Application WB		$229.00
pAb	ARP33491_T100	WNT8B antibody - middle region (ARP33491_T100) Reacts with Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, African clawed frog, Chicken, Zebrafish Application WB	Human Brain	$229.00
pAb	ARP41236_P050	FZD2 antibody - N-terminal region (ARP41236_P050) Reacts with Bovine, Dog, Horse, Human, Mouse, Rat Application WB	Human Spleen	$289.00
pAb	ARP50670_P050	CTBP2 antibody - C-terminal region (ARP50670_P050) Reacts with Bovine, Chicken, Dog, Human, Mouse, Rat, Horse, Goat Application WB, IHC	Human HeLa Mouse retina Mouse retina	$289.00
pAb	ARP41285_P050	NKD1 antibody - N-terminal region (ARP41285_P050) Reacts with Guinea pig, Human, Dog, Chicken, Bovine, Mouse, Rat Application WB, IHC	Human HepG2 Human Lung	$289.00
pAb	ARP56124_P050	PPP3R1 antibody - N-terminal region (ARP56124_P050) Reacts with African clawed frog, Chicken, Human, Rabbit, Rat, Zebrafish Application WB	Human NCI-H226	$289.00
pAb	ARP41280_T100	WNT5B antibody - C-terminal region (ARP41280_T100) Reacts with Human, Chicken, Dog, Pig, Rabbit, African clawed frog, Bovine, Guinea pig, Mouse, Rat Application WB	Human HepG2	$229.00
pAb	ARP32128_P050	WNT5A antibody - middle region (ARP32128_P050) Reacts with Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, African clawed frog, Chicken Application WB, IHC	Human HeLa Human Placenta Human Colon	$289.00
pAb	ARP31378_P050	FOSL1 antibody - middle region (ARP31378_P050) Reacts with Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat Application WB	Human HepG2 Human Lung	$289.00
pAb	P100911_P050	JUN antibody - N-terminal region (P100911_P050) Reacts with Human, Bovine, Dog, Mouse, Pig, Rabbit, Rat, Sheep Application WB	Human 293T	$289.00
pAb	ARP55131_P050	DAAM1 antibody - middle region (ARP55131_P050) Reacts with Bovine, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Dog, Chicken, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP49762_P050	PORCN antibody - N-terminal region (ARP49762_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat Application WB, IHC	Human HepG2 Mouse Uterus	$289.00
pAb	ARP38493_P050	NFATC4 antibody - N-terminal region (ARP38493_P050) Reacts with Bovine, Dog, Guinea pig, Horse, Human, Pig, Rabbit, Rat Application WB	Human 721_B	$289.00
pAb	ARP32101_T100	DVL1 antibody - C-terminal region (ARP32101_T100) Reacts with Human, Pig, Bovine, Dog, Horse, Mouse, Rat Application WB	Human K562	$229.00
pAb	ARP41268_T100	WNT16 antibody - C-terminal region (ARP41268_T100) Reacts with Bovine, Human, Rabbit, Chicken, Dog, Mouse, Rat Application WB	Human HepG2	$229.00
pAb	ARP53596_P050	CSNK2A2 antibody - C-terminal region (ARP53596_P050) Reacts with Bovine, Dog, Horse, Pig, Rabbit, Guinea pig, Mouse, Rat Application WB	Human HepG2	$289.00
pAb	P100975_P050	NFATC3 antibody - N-terminal region (P100975_P050) Reacts with Bovine, Chicken, Dog, Horse, Human, Mouse, Rat, African clawed frog Application WB, IHC	Human HeLa Human Thymus	$289.00
pAb	ARP56426_P050	PRKCG antibody - middle region (ARP56426_P050) Reacts with Bovine, Dog, Horse, Human, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP46733_P050	WNT6 antibody - middle region (ARP46733_P050) Reacts with Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat Application WB	Human 293T	$289.00
pAb	ARP57781_P050	PPP2R1B antibody - N-terminal region (ARP57781_P050) Reacts with Human, African clawed frog, Bovine, Dog, Guinea pig, Horse, Mouse, Rabbit, Rat, Zebrafish Application WB	Human Thymus	$289.00
pAb	ARP38605_P050	SMAD4 antibody - N-terminal region (ARP38605_P050) Reacts with African clawed frog, Bovine, Goat, Guinea pig, Horse, Human, Mouse, Pig, Rat Application WB	Human 293T	$289.00

Aviva Systems Biology

Wnt Signaling Pathway

Reacts with

Application

WB

Reacts with

Mouse, Horse, Human, Rat, Bovine, Dog, Pig

Application

WB

Reacts with

Application

ELISA, IHC-FFPE, WB

Reacts with

Human, Dog, Mouse, Guinea pig

Application

WB

Reacts with

Human, Rat, Mouse

Application

WB

Reacts with

African clawed frog, Bovine, Dog, Horse, Human, Mouse, Rabbit, Zebrafish, Chicken

Application

WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Zebrafish

Application

WB

Reacts with

African clawed frog, Chicken, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat, Zebrafish

Application

WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Pig, Rat, Zebrafish

Application

WB

Reacts with

Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rat, Zebrafish

Application

WB

Reacts with

Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, African clawed frog, Chicken, Zebrafish

Application

WB

Reacts with

Bovine, Dog, Horse, Human, Mouse, Rat

Application

WB

Reacts with

Bovine, Chicken, Dog, Human, Mouse, Rat, Horse, Goat

Application

WB, IHC

Reacts with

Guinea pig, Human, Dog, Chicken, Bovine, Mouse, Rat

Application

WB, IHC

Reacts with

African clawed frog, Chicken, Human, Rabbit, Rat, Zebrafish

Application

WB

Reacts with

Human, Chicken, Dog, Pig, Rabbit, African clawed frog, Bovine, Guinea pig, Mouse, Rat

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, African clawed frog, Chicken

Application

WB, IHC

Reacts with

Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat

Application

WB

Reacts with

Human, Bovine, Dog, Mouse, Pig, Rabbit, Rat, Sheep

Application

WB

Reacts with

Bovine, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Dog, Chicken, Zebrafish

Application

WB