Wnt Signaling Pathway

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.^[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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Type	Catalog #	Product	Product Images	Price (USD)
mAb	OASA02653	CCND3 Antibody (OASA02653) Reacts with Application IHC-AFF, IHC-FFPE, WB		$1,075.00
mAb	OASA00562	CCND1 Antibody (OASA00562) Reacts with Application IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB		$470.00
mAb	OASA03763	PRKCB Antibody (OASA03763) Reacts with Application IHC-AFF		$435.00
mAb	OASA03187	TP53 Antibody (OASA03187) Reacts with Application IHC-AFF, IP, IHC-FFPE, WB		$390.00
mAb	OASA00564	CCND2 Antibody (OASA00564) Reacts with Application IHC-AFF, IP, WB		$700.00
mAb	OASA00538	MYC Antibody (OASA00538) Reacts with Application IHC-AFF, ELISA, FC, IHC-FFPE, WB	c-myc tagged protein	$705.00
mAb	OASA03762	PRKCA Antibody (OASA03762) Reacts with Application IHC-AFF, WB		$390.00
pAb	OASA06336	SMAD2 Antibody (OASA06336) Reacts with Application WB		$655.00
pAb	ARP41262_P050	FZD10 antibody - N-terminal region (ARP41262_P050) Reacts with Bovine, Chicken, Dog, Horse, Human, Mouse, African clawed frog, Zebrafish Application WB	Human HepG2	$289.00
pAb	OASA06406	PSEN1 Antibody (OASA06406) Reacts with Application IHC-AFF, ELISA, IHC-FFPE, WB		$390.00
pAb	ARP38831_P050	NFAT5 antibody - middle region (ARP38831_P050) Reacts with Guinea pig, Human, Bovine, Rabbit, Dog, Horse, Pig Application WB	Human MCF-7	$289.00
pAb	OASA06465	MAP3K7 Antibody (OASA06465) Reacts with Application ELISA, WB		$505.00
pAb	AVARP03049_T100	CUL1 antibody - C-terminal region (AVARP03049_T100) Reacts with African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Zebrafish Application WB	Human Jurkat	$229.00
pAb	ARP32128_P050	WNT5A antibody - middle region (ARP32128_P050) Reacts with Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, African clawed frog, Chicken Application WB, IHC	Human HeLa Human Placenta Human Colon	$289.00
pAb	OASA07131	CTNNB1 Antibody (OASA07131) Reacts with Application IHC-AFF, ELISA, WB, IP, IHC-FFPE		$795.00
pAb	ARP56426_P050	PRKCG antibody - middle region (ARP56426_P050) Reacts with Bovine, Dog, Horse, Human, Zebrafish Application WB	Human 293T	$289.00
pAb	ARP57548_P050	SENP2 antibody - middle region (ARP57548_P050) Reacts with Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat Application WB	Human COLO205	$289.00
pAb	ARP57798_P050	RAC1 antibody - middle region (ARP57798_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish Application WB	Human HepG2	$289.00
pAb	OASA07643	CREBBP Antibody (OASA07643) Reacts with Application IP, WB		$630.00
pAb	ARP51987_P050	CSNK1E antibody - N-terminal region (ARP51987_P050) Reacts with African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Pig, Rat, Zebrafish Application WB	Human THP-1	$289.00
pAb	OASA08759	SFRP1 Antibody (OASA08759) Reacts with Application ELISA, IHC-FFPE, WB		$655.00
pAb	ARP46733_P050	WNT6 antibody - middle region (ARP46733_P050) Reacts with Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat Application WB	Human 293T	$289.00
pAb	OASA06330	LEF1 Antibody (OASA06330) Reacts with Application ELISA, WB		$505.00
pAb	ARP41280_T100	WNT5B antibody - C-terminal region (ARP41280_T100) Reacts with Human, Chicken, Dog, Pig, Rabbit, African clawed frog, Bovine, Guinea pig, Mouse, Rat Application WB	Human HepG2	$229.00
pAb	OASA06402	PPP2R5D Antibody (OASA06402) Reacts with Application WB		$520.00
pAb	ARP41236_P050	FZD2 antibody - N-terminal region (ARP41236_P050) Reacts with Bovine, Dog, Horse, Human, Mouse, Rat Application WB	Human Spleen	$289.00
pAb	OASA06437	SFRP2 antibody - C-terminal region (OASA06437) Reacts with Application ELISA, WB		$505.00
pAb	P100911_P050	JUN antibody - N-terminal region (P100911_P050) Reacts with Human, Bovine, Dog, Mouse, Pig, Rabbit, Rat, Sheep Application WB	Human 293T	$289.00
pAb	ARP37106_T100	NFATC2 antibody - N-terminal region (ARP37106_T100) Reacts with Mouse, Horse, Human, Rat, Bovine, Dog, Pig Application WB	Mouse SP2/0	$229.00
pAb	OASA07100	PPP3CA Antibody (OASA07100) Reacts with Application IHC-AFF, WB		$1,535.00

Aviva Systems Biology

Wnt Signaling Pathway

Reacts with

Application

IHC-AFF, IHC-FFPE, WB

Reacts with

Application

IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB

Reacts with

Application

IHC-AFF

Reacts with

Application

IHC-AFF, IP, IHC-FFPE, WB

Reacts with

Application

IHC-AFF, IP, WB

Reacts with

Application

IHC-AFF, ELISA, FC, IHC-FFPE, WB

Reacts with

Application

IHC-AFF, WB

Reacts with

Application

WB

Reacts with

Bovine, Chicken, Dog, Horse, Human, Mouse, African clawed frog, Zebrafish

Application

WB

Reacts with

Application

IHC-AFF, ELISA, IHC-FFPE, WB

Reacts with

Guinea pig, Human, Bovine, Rabbit, Dog, Horse, Pig

Application

WB

Reacts with

Application

ELISA, WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Human, Mouse, Rat, Zebrafish

Application

WB

Reacts with

Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, African clawed frog, Chicken

Application

WB, IHC

Reacts with

Application

IHC-AFF, ELISA, WB, IP, IHC-FFPE

Reacts with

Bovine, Dog, Horse, Human, Zebrafish

Application

WB

Reacts with

Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat

Application

WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish

Application

WB

Reacts with

Application

IP, WB

Reacts with

African clawed frog, Bovine, Chicken, Dog, Guinea pig, Human, Mouse, Pig, Rat, Zebrafish

Application

WB

Reacts with

Application

ELISA, IHC-FFPE, WB

Reacts with

Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat

Application

WB

Reacts with

Application

ELISA, WB