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Wnt Signaling

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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    WNT1 Antibody (OASA08277)

    WNT1 Antibody (OASA08277)

    Protein Name:Proto-oncogene Wnt-1
    Catalog #:OASA08277
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $555.00
  •  
    TP53 Antibody (OASA03187)

    TP53 Antibody (OASA03187)

    Protein Name:Cellular tumor antigen p53
    Catalog #:OASA03187
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IP, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $410.00
  •  
    WNT2B Antibody (OASA08917)

    WNT2B Antibody (OASA08917)

    Protein Name:Protein Wnt-2b
    Catalog #:OASA08917
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE
    Product Size: 50ug
    Price (USD): $750.00
  •  
    LRP6 Antibody (OASA06335)

    LRP6 Antibody (OASA06335)

    Protein Name:Low-density lipoprotein receptor-related protein 6
    Catalog #:OASA06335
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE
    Product Size: 50ug
    Price (USD): $675.00
  •  
    Human PPP2R5C Antibody (OASA06401)

    Human PPP2R5C Antibody (OASA06401)

    Protein Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    Catalog #:OASA06401
    Type: pAb
    Reacts with:
    Application: WB
    Product Size: 0.1mg
    Price (USD): $490.00
  •  
    RAC2 Antibody (OASA06415)

    RAC2 Antibody (OASA06415)

    Protein Name:Ras-related C3 botulinum toxin substrate 2
    Catalog #:OASA06415
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $560.00
  •  
    CCND2 Antibody (OASA00564)

    CCND2 Antibody (OASA00564)

    Protein Name:G1/S-specific cyclin-D2
    Catalog #:OASA00564
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IP, WB
    Product Size: 0.1mg
    Price (USD): $735.00
  •  
    SFRP1 Antibody (OASA08759)

    SFRP1 Antibody (OASA08759)

    Protein Name:Secreted frizzled-related protein 1
    Catalog #:OASA08759
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $690.00
  •  
    FZD4 Antibody (OASA06098)

    FZD4 Antibody (OASA06098)

    Protein Name:Frizzled-4
    Catalog #:OASA06098
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    PRKCA Antibody (OASA03762)

    PRKCA Antibody (OASA03762)

    Protein Name:Protein kinase C alpha type
    Catalog #:OASA03762
    Type: mAb
    Reacts with:
    Application: IHC-AFF, WB
    Product Size: 2ml
    Price (USD): $400.00
  •  
    SMAD2 Antibody (OASA06336)

    SMAD2 Antibody (OASA06336)

    Protein Name:Mothers against decapentaplegic homolog 2
    Catalog #:OASA06336
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $690.00
  •  
    PPP2R5D Antibody (OASA06402)

    PPP2R5D Antibody (OASA06402)

    Protein Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
    Catalog #:OASA06402
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $545.00

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