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Wnt Signaling

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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    PPP2CA Antibody (OASA06410)

    PPP2CA Antibody (OASA06410)

    Protein Name:Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Catalog #:OASA06410
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $790.00
  •  
    CTBP1 Antibody (OASA07187)

    CTBP1 Antibody (OASA07187)

    Protein Name:C-terminal-binding protein 1
    Catalog #:OASA07187
    Type: pAb
    Reacts with: Human, Mouse
    Application: IF, IP, WB
    Product Size: 0.1mg
    Price (USD): $410.00
  •  
    CCND1 Antibody (OASA00562)

    CCND1 Antibody (OASA00562)

    Protein Name:G1/S-specific cyclin-D1
    Catalog #:OASA00562
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $490.00
  •  
    CREBBP Antibody (OASA07643)

    CREBBP Antibody (OASA07643)

    Protein Name:CREB-binding protein
    Catalog #:OASA07643
    Type: pAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $640.00
  •  
    PRKCB Antibody (OASA03763)

    PRKCB Antibody (OASA03763)

    Protein Name:Protein kinase C beta type
    Catalog #:OASA03763
    Type: mAb
    Reacts with:
    Application: IHC-AFF
    Product Size: 2ml
    Price (USD): $455.00
  •  
    Ppard Antibody (OASA08597)

    Ppard Antibody (OASA08597)

    Protein Name:Peroxisome proliferator-activated receptor delta
    Catalog #:OASA08597
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $725.00
  •  
    MMP7 Antibody (OASA06351)

    MMP7 Antibody (OASA06351)

    Protein Name:Matrilysin
    Catalog #:OASA06351
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    PPP2R5E Antibody (OASA06403)

    PPP2R5E Antibody (OASA06403)

    Protein Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
    Catalog #:OASA06403
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $560.00
  •  
    SIAH1 Antibody (OASA06445)

    SIAH1 Antibody (OASA06445)

    Protein Name:E3 ubiquitin-protein ligase SIAH1
    Catalog #:OASA06445
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $545.00

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