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100ug
$229.00
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TPM1 antibody - N-terminal region (ARP41392_T100)

Description of Target:
TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
Gene Symbol:
TPM1
Official Gene Full Name:
Tropomyosin 1 (alpha)
NCBI Gene Id:
7168
Alias Symbols:
CMH3; TMSA; TPM1-alpha; CMD1Y; C15orf13; HTM-alpha
Tissue Tool:
Find tissues and cell lines supported to express TPM1.
Protein Accession #:
NP_000357
Nucleotide Accession#:
NM_000366
Swissprot Id:
P09493
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
Tropomyosin alpha-1 chain
Protein Size (# AA):
284
Molecular Weight:
31kDa
Application:
IHC, WB
Partner Proteins:
C1QA, C1QB, FCGR1A, FGA, PLG, THBS1, FGA
Immunogen:
The immunogen for anti-TPM1 antibody: synthetic peptide directed towards the N terminal of human TPM1
Product Format:
Lyophilized powder
Purification:
Protein A purified
Complete computational species homology data:
TPM1 antibody - N-terminal region (ARP41392_T100)
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Pig: 100%; Rat: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Zebrafish: 100%; Guinea pig: 100%; Horse: 93%; Sheep: 93%; Bovine: 93%
Species Reactivity:
Human, Zebrafish, Mouse, Dog, Rabbit, Rat, Guinea pig, Sheep, Horse, Bovine
Datasheets / Downloads:
Printable datasheet for
anti-TPM1 antibody
- ARP41392_T100
Peptide Sequence:
Synthetic peptide located within the following region: DRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQE
Blocking Peptide:
For anti-TPM1 antibody is Catalog # AAP41392 (Previous Catalog # AAPP24130)
Key Reference:
Lin,J.C. (2005) Mol. Cell. Biol. 25 (22), 10111-10121
Reconstitution and Storage:
Add 100 ul of distilled water. Final anti-TPM1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
 
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