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TPM1 antibody - N-terminal region (ARP41392_T100)

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100 ul

Regular Price: $229.00

Special Price: $185.00

In Stock

Conjugation Options

ARP41392_T100-FITC Conjugated

ARP41392_T100-HRP Conjugated

ARP41392_T100-Biotin Conjugated

Gene Symbol:
TPM1
NCBI Gene Id:
7168
Official Gene Full Name:
Tropomyosin 1 (alpha)
Protein Name:
Tropomyosin alpha-1 chain
Swissprot Id:
P09493
Protein Accession #:
NP_000357
Nucleotide Accession #:
NM_000366
Alias Symbols:
CMH3, TMSA, TPM1-alpha, CMD1Y, C15orf13, HTM-alpha
Replacement Item:
This antibody may replace item sc-159958 from Santa Cruz Biotechnology.
Description of Target:
TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
Protein Size (# AA):
284
Molecular Weight:
31kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TPM1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TPM1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human TPM1
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%; Zebrafish: 100%
Complete computational species homology data:
Anti-TPM1 (ARP41392_T100)
Peptide Sequence:
Synthetic peptide located within the following region: DRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQE
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
GOLGA2; CAGE1; C1orf216; SYCE1; KXD1; TFPT; MAD1L1; TPM4; TP53; TNNT1; UBC; MDM2; ETFA; FOXK1; KIAA1598; PPP6R3; APPL2; CDC37; MGEA5; STUB1; ABI2; DNAJC7; HSP90B1; PARK2; LRCH3; PAN2; TGFBR1; SPTBN1; ATF2; MDC1; BRCA1; PPP4R2; SRXN1; NUDCD2; RBM15; THOC2;
Blocking Peptide:
For anti-TPM1 (ARP41392_T100) antibody is Catalog # AAP41392 (Previous Catalog # AAPP24130)
Datasheets / Downloads:
Printable datasheet for anti-TPM1 (ARP41392_T100) antibody
Target Reference:
Lin,J.C. (2005) Mol. Cell. Biol. 25 (22), 10111-10121

Product Protocols: TPM1 antibody tested with Human Hepg2 Cells (ARP41392_T100)

Aviva Systems Biology is the original manufacturer of this TPM1 antibody (ARP41392_T100)

Click here to view the TPM1 antibody Western Blot Protocol

Product Datasheet Link: TPM1 antibody (ARP41392_T100)

WB Suggested Anti-TPM1 Antibody Titration: 1.25ug/ml
Positive Control: HepG2

Western Blot image:


Description of Target: TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction.This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s TPM1 antibody (ARP41392_T100) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

Product Protocols: TPM1 antibody tested by IHC with human muscle (ARP41392)

Aviva Systems Biology is the original manufacturer of this TPM1 antibody.

Click here to view the TPM1 antibody Immunohistochemistry (IHC) protocol

Product Datasheet Link: TPM1 antibody (ARP41392)

IHC Information:

Rabbit Anti-TPM1 Antibody
Catalog Number: ARP41392
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X

IHC Image:

 
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