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Catalog No: ARP41388_P050
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ARP41388_P050
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Datasheets/ManualsPrintable datasheet for anti-SLC12A1 (ARP41388_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human SLC12A1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: NEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANI
Concentration0.5 mg/ml
Blocking PeptideFor anti-SLC12A1 (ARP41388_P050) antibody is Catalog # AAP41388 (Previous Catalog # AAPP24126)
Enhanced Validation
WBY
SPR
YCHAROS
Publications

Kelsen, S. et al. Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells. Am. J. Physiol. Renal Physiol. 295, F1158-65 (2008). 18701634

Polyuria-associated hydronephrosis induced by xenobiotic chemical exposure in mice. Am. J. Physiol. Renal Physiol. 311, F752-F762 (2016). 27440775

Stec, D. E. et al. Expression of heme oxygenase-1 in thick ascending loop of henle attenuates angiotensin II-dependent hypertension. J. Am. Soc. Nephrol. 23, 834-41 (2012). 22323644

Gene SymbolSLC12A1
Gene Full NameSolute carrier family 12 (sodium/potassium/chloride transporters), member 1
Alias SymbolsBSC1, NKCC2
NCBI Gene Id6557
Protein NameSLC12A1 protein EMBL AAH40138.1
Description of TargetThe sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
Uniprot IDQ8IUN5
Protein Accession #AAH40138
Nucleotide Accession #NM_000338
Protein Size (# AA)430
Molecular Weight47kDa
Protein InteractionsSTK39; OXSR1;
  1. What is the species homology for "SLC12A1 Antibody - N-terminal region (ARP41388_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit".

  2. How long will it take to receive "SLC12A1 Antibody - N-terminal region (ARP41388_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "SLC12A1 Antibody - N-terminal region (ARP41388_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SLC12A1 Antibody - N-terminal region (ARP41388_P050)"?

    This target may also be called "BSC1, NKCC2" in publications.

  5. What is the shipping cost for "SLC12A1 Antibody - N-terminal region (ARP41388_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SLC12A1 Antibody - N-terminal region (ARP41388_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SLC12A1 Antibody - N-terminal region (ARP41388_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "47kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SLC12A1 Antibody - N-terminal region (ARP41388_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "SLC12A1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "SLC12A1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "SLC12A1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "SLC12A1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "SLC12A1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "SLC12A1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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