Catalog No: ARP41372_P050
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ARP41372_P050
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Datasheets/ManualsPrintable datasheet for anti-HSD11B2 (ARP41372_P050) antibody
Product Info
Tested Species ReactivityHuman, Rat
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Sheep
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B2
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
Peptide SequenceSynthetic peptide located within the following region: ERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRL
Concentration0.5 mg/ml
Blocking PeptideFor anti-HSD11B2 (ARP41372_P050) antibody is Catalog # AAP41372 (Previous Catalog # AAPP24110)
ReferenceHovanessian,A.G., (2008) Mol. Cell. Biol. 28 (11), 3830-3849
Publications

Ancestral androgenic differentiation pathways are repurposed during the evolution of adult sexual plasticity. Evol Dev. 18, 285-296 (2016) 27870212

Description
Gene SymbolHSD11B2
Gene Full NameHydroxysteroid (11-beta) dehydrogenase 2
Alias SymbolsAME, AME1, HSD2, HSD11K, SDR9C3
NCBI Gene Id3291
Protein NameCorticosteroid 11-beta-dehydrogenase isozyme 2
Description of TargetHSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. It modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Uniprot IDP80365
Protein Accession #NP_000187
Nucleotide Accession #NM_000196
Protein Size (# AA)44
Molecular Weight45kDa
Protein InteractionsKAT2B; HDAC1; KAT2A; CTBP1;
  1. What is the species homology for "HSD11B2 Antibody - N-terminal region (ARP41372_P050)"?

    The tested species reactivity for this item is "Human, Rat". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Sheep".

  2. How long will it take to receive "HSD11B2 Antibody - N-terminal region (ARP41372_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "HSD11B2 Antibody - N-terminal region (ARP41372_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "HSD11B2 Antibody - N-terminal region (ARP41372_P050)"?

    This target may also be called "AME, AME1, HSD2, HSD11K, SDR9C3" in publications.

  5. What is the shipping cost for "HSD11B2 Antibody - N-terminal region (ARP41372_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "HSD11B2 Antibody - N-terminal region (ARP41372_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "HSD11B2 Antibody - N-terminal region (ARP41372_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "45kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "HSD11B2 Antibody - N-terminal region (ARP41372_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "HSD11B2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "HSD11B2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "HSD11B2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "HSD11B2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "HSD11B2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "HSD11B2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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