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Catalog No: ARP42752_P050
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ARP42752_P050
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
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Datasheets/ManualsPrintable datasheet for anti-CLEC4M (ARP42752_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Horse, Pig
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human CLEC4M
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHorse: 79%; Human: 100%; Pig: 93%
Peptide SequenceSynthetic peptide located within the following region: CYFMSNSQRNWHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWM
Concentration0.5 mg/ml
Blocking PeptideFor anti-CLEC4M (ARP42752_P050) antibody is Catalog # AAP42752 (Previous Catalog # AAPP24975)
Gene SymbolCLEC4M
Gene Full NameC-type lectin domain family 4, member M
Alias SymbolsCD299, LSIGN, CD209L, L-SIGN, DCSIGNR, HP10347, DC-SIGN2, DC-SIGNR
NCBI Gene Id10332
Protein NameC-type lectin domain family 4 member M
Description of TargetCLEC4M is a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity.
Uniprot IDQ9H2X3
Protein Accession #NP_001138378
Nucleotide Accession #NM_001144906
Protein Size (# AA)263
Molecular Weight30kDa
Protein InteractionsTLR2; MME; CLEC4M; CD209; ICAM3; ITGAM; AP2M1; HCVgp1;
  1. What is the species homology for "CLEC4M Antibody - middle region (ARP42752_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Horse, Pig".

  2. How long will it take to receive "CLEC4M Antibody - middle region (ARP42752_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CLEC4M Antibody - middle region (ARP42752_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CLEC4M Antibody - middle region (ARP42752_P050)"?

    This target may also be called "CD299, LSIGN, CD209L, L-SIGN, DCSIGNR, HP10347, DC-SIGN2, DC-SIGNR" in publications.

  5. What is the shipping cost for "CLEC4M Antibody - middle region (ARP42752_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CLEC4M Antibody - middle region (ARP42752_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CLEC4M Antibody - middle region (ARP42752_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "30kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CLEC4M Antibody - middle region (ARP42752_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CLEC4M"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CLEC4M"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CLEC4M"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CLEC4M"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CLEC4M"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CLEC4M"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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