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Catalog No: OASA03360 (Formerly GWB-26CB58)
Size:200UG
Price: $499.00
SKU
OASA03360
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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TSHR Antibody (OASA03360)

Datasheets/ManualsPrintable datasheet for TSHR Antibody (OASA03360)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. Phosphate buffered saline
ClonalityMonoclonal
Clone2C11
IsotypeIgG1
HostMouse
ApplicationEnzyme-linked immunosorbent assay|Flow cytometry|Immunoprecipitation|Western blot
Additional InformationFusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the NS1/Ag4.1 mouse myeloma cell line.
::Preservative Stabilisers: 0.09% - Sodium Azide
::Approx Protein Conc: IgG concentration 1.0 mg/ml
Buffer Solutions: Phosphate buffered saline
Reconstitution and Storage-20°C
ImmunogenRecombinant Human TSH receptor.
PurificationProtein A Purified
Predicted Homology Based on Immunogen SequenceHuman
Concentration1 mg/ml
SpecificityMouse anti Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid.

Mouse anti Human thyroid stimulating receptor antibody recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors.

Clone 2C11 recognises the mutant TSH receptor known as I167N as well as the wild type molecule (Costagliola et al. 1998)
Application InfoImmunoprecipitation: 5ug/ml - 10ug/ml
Western Blotting: 5ug/ml - 10ug/ml
Reference1. Johnstone, A.P. et al. (1994) Monoclonal antibodies that recognise the native human thyrotropin receptor. Mol. Cell. Endocrin. 105: R1-R9.
2. Costagliola, S. et al. (1998) Genetic immunization against the human thyrotrophin receptor causes thyroiditis and allows production of monoclonal antibodies recognising the native receptor. J. Immunol. 160: 1458-1465.
3. Haas, A.K. et al. (2010) Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.
Gene SymbolTSHR
Alias SymbolsLGR3, CHNG1, hTSHR-I
NCBI Gene Id7253
Protein NameThyrotropin receptor
Description of TargetMOUSE ANTI HUMAN TSH RECEPTOR
Uniprot IDP16473
Protein Accession #NP_000360.2
Protein Size (# AA)764
  1. What is the species homology for "TSHR Antibody (OASA03360)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "TSHR Antibody (OASA03360)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "TSHR Antibody (OASA03360)" provided in?

    This item is provided in "Liquid. Phosphate buffered saline".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TSHR Antibody (OASA03360)"?

    This target may also be called "LGR3, CHNG1, hTSHR-I" in publications.

  5. What is the shipping cost for "TSHR Antibody (OASA03360)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TSHR Antibody (OASA03360)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TSHR Antibody (OASA03360)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TSHR Antibody (OASA03360)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TSHR"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TSHR"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TSHR"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TSHR"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TSHR"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TSHR"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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