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Datasheets/Manuals | Printable datasheet for TSHR Antibody (OASA03360) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid. Phosphate buffered saline |
Clonality | Monoclonal |
Clone | 2C11 |
Isotype | IgG1 |
Host | Mouse |
Application | Enzyme-linked immunosorbent assay|Flow cytometry|Immunoprecipitation|Western blot |
Additional Information | Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the NS1/Ag4.1 mouse myeloma cell line. |
:: | Preservative Stabilisers: 0.09% - Sodium Azide |
:: | Approx Protein Conc: IgG concentration 1.0 mg/ml Buffer Solutions: Phosphate buffered saline |
Reconstitution and Storage | -20°C |
Immunogen | Recombinant Human TSH receptor. |
Purification | Protein A Purified |
Predicted Homology Based on Immunogen Sequence | Human |
Concentration | 1 mg/ml |
Specificity | Mouse anti Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid. Mouse anti Human thyroid stimulating receptor antibody recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors. Clone 2C11 recognises the mutant TSH receptor known as I167N as well as the wild type molecule (Costagliola et al. 1998) |
Application Info | Immunoprecipitation: 5ug/ml - 10ug/ml Western Blotting: 5ug/ml - 10ug/ml |
Reference | 1. Johnstone, A.P. et al. (1994) Monoclonal antibodies that recognise the native human thyrotropin receptor. Mol. Cell. Endocrin. 105: R1-R9. 2. Costagliola, S. et al. (1998) Genetic immunization against the human thyrotrophin receptor causes thyroiditis and allows production of monoclonal antibodies recognising the native receptor. J. Immunol. 160: 1458-1465. 3. Haas, A.K. et al. (2010) Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor. |
Gene Symbol | TSHR |
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Alias Symbols | LGR3, CHNG1, hTSHR-I |
NCBI Gene Id | 7253 |
Protein Name | Thyrotropin receptor |
Description of Target | MOUSE ANTI HUMAN TSH RECEPTOR |
Uniprot ID | P16473 |
Protein Accession # | NP_000360.2 |
Protein Size (# AA) | 764 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "TSHR Antibody (OASA03360)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "TSHR Antibody (OASA03360)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "TSHR Antibody (OASA03360)" provided in?
This item is provided in "Liquid. Phosphate buffered saline".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TSHR Antibody (OASA03360)"?
This target may also be called "LGR3, CHNG1, hTSHR-I" in publications.
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What is the shipping cost for "TSHR Antibody (OASA03360)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "TSHR Antibody (OASA03360)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TSHR Antibody (OASA03360)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TSHR Antibody (OASA03360)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TSHR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TSHR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TSHR"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TSHR"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TSHR"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TSHR"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.