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Catalog No: ARP56494_P050
Price: $0.00
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ARP56494_P050
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Datasheets/ManualsPrintable datasheet for anti-PTPN11 (ARP56494_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human PTPN11
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: HPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTD
Concentration0.5 mg/ml
Blocking PeptideFor anti-PTPN11 (ARP56494_P050) antibody is Catalog # AAP56494 (Previous Catalog # AAPP39002)
Gene SymbolPTPN11
Gene Full NameProtein tyrosine phosphatase, non-receptor type 11
Alias SymbolsCFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3
NCBI Gene Id5781
Protein NameTyrosine-protein phosphatase non-receptor type 11
Description of TargetThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Uniprot IDQ06124-2
Protein Accession #NP_002825
Nucleotide Accession #NM_002834
Protein Size (# AA)593
Molecular Weight68kDa
Protein InteractionsTRIM32; RPIA; UBC; NEDD8; SUMO1; MTPN; EFHD2; CHRAC1; OXCT1; MAPK14; GRB2; Siglece; GAB2; GAB1; VCAM1; CD274; IQCB1; IRS1; ERBB2; EGFR; FASN; RFWD2; FRS2; PPIF; GSK3B; CRK; PIK3R2; PIK3R1; MAP3K5; LRRK1; CSF2RBP1; FYN; CBL; SOCS3; CXCR4; MYC; INPP5D; IL6S
  1. What is the species homology for "PTPN11 Antibody - N-terminal region (ARP56494_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "PTPN11 Antibody - N-terminal region (ARP56494_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "PTPN11 Antibody - N-terminal region (ARP56494_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PTPN11 Antibody - N-terminal region (ARP56494_P050)"?

    This target may also be called "CFC, NS1, JMML, SHP2, BPTP3, PTP2C, METCDS, PTP-1D, SH-PTP2, SH-PTP3" in publications.

  5. What is the shipping cost for "PTPN11 Antibody - N-terminal region (ARP56494_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PTPN11 Antibody - N-terminal region (ARP56494_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PTPN11 Antibody - N-terminal region (ARP56494_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "68kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PTPN11 Antibody - N-terminal region (ARP56494_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PTPN11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PTPN11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PTPN11"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PTPN11"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PTPN11"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PTPN11"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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