HNF4A Antibody - N-terminal region (ARP31946_P050)

Catalog No: ARP31946_P050

Host: Rat
Target Name: HNF4A
Sample Tissue: Rat Skeletal Muscle
Antibody Dilution: 1ug/ml

Host: Rabbit
Target Name: HNF4A
Sample Tissue: Human Lung Tumor
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human, Rat
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HNF4A
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 93%
• Peptide Sequence: Synthetic peptide located within the following region: MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNA
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-HNF4A (ARP31946_P050) antibody is Catalog # AAP31946
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Publications:

  AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation. Genome Biol. 14, R124 (2013). 24200198

  Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice. J Biol Chem. 289, 3105-13 (2014). 24318876

  Faure, A. J. et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22, 2163-75 (2012). 22780989

  Schmidt, D. et al. A CTCF-independent role for cohesin in tissue-specific transcription. Genome Res. 20, 578-88 (2010). 20219941

• Description:
  View product citations for HNF4A Antibody - N-terminal region (ARP31946_P050) on CiteAb

Target Info

• Gene Symbol: HNF4A
• Gene Full Name: Hepatocyte nuclear factor 4, alpha
• Alias Symbols: TCF, HNF4, MODY, FRTS4, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha
• NCBI Gene Id: 3172
• Protein Name: Hepatocyte nuclear factor 4-alpha
• Description of Target: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.
• Uniprot ID: P41235
• Protein Accession #: NP_000448
• Nucleotide Accession #: NM_000457
• Protein Size (# AA): 474
• Molecular Weight: 53kDa
• Protein Interactions: PIAS4; SUMO1; SUMO2; RNF4; SUB1; CREBBP; TBP; TAF9; TAF6; TADA2A; GTF2H1; GTF2B; ANP32B; MDM2; GPS2; PPARGC1A; HNF4A; NCOA6; SMAD4; SMAD3; PNRC2; COPS5; PNRC1; NR0B2; NRIP1; UBE2I; PROX1; NPPA; SREBF2; VDR; MAPK3; MAPK1; SIRT1; SREBF1; XPO1; SP1; HDAC3; T