CRYAB Antibody - C-terminal region (ARP48196_T100)

Catalog No: ARP48196_T100

WB Suggested Anti-CRYAB Antibody Titration: 5.0ug/ml
Positive Control: Jurkat cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CRYAB
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Sheep: 92%
• Peptide Sequence: Synthetic peptide located within the following region: KYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVT
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-CRYAB (ARP48196_T100) antibody is Catalog # AAP48196 (Previous Catalog # AAPS22707)

Target Info

• Gene Symbol: CRYAB
• Gene Full Name: Crystallin, alpha B
• Alias Symbols: MFM2, CRYA2, CTPP2, HSPB5, CMD1II, CTRCT16, HEL-S-101
• NCBI Gene Id: 1410
• Protein Name: Alpha-crystallin B chain
• Description of Target: Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.
• Uniprot ID: P02511
• Protein Accession #: EAW67166
• Nucleotide Accession #: NM_001885
• Protein Size (# AA): 175
• Molecular Weight: 20kDa
• Protein Interactions: CRYAB; CRYAA; KRTAP19-5; KRTAP8-1; TRAPPC6A; MRPL11; TNPO2; ACOT7; HSPB1; CASP7; CASP3; CASP2; PIDD1; DDX20; CRADD; B2M; APOC2; XIAP; CASP12; SOD1; HSPB2; HBA1; CASP9; CASP8; CASP6; ASB5; SMAD4; TRIM33; UBC; CCL22; CTNNB1; CRYGD; CDH1; SNCA; GFAP; FGF2; F