KHDRBS1 antibody - N-terminal region (ARP40665_P050)

Catalog#: ARP40665_P050

• Size: 50ug

Human Heart

• Description of Target: KHDRBS1 recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, KHDRBS1 functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. KHDRBS1 play a role in G2-M progression in the cell cycle. It represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. KHDRBS1 also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.
• Gene Symbol: KHDRBS1
• Official Gene Full Name: KH domain containing, RNA binding, signal transduction associated 1
• Alias Symbols: FLJ34027; Sam68; p62; p68
• Protein Accession#: NP_006550
• Nucleotide Accession#: NM_006559
• Swissprot Id: Q07666
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 443
• Molecular Weight: 48kDa
• Application: WB
• Partner Proteins: GRAP2, GRB2, HCK, HNRNPK, HNRNPK, LCK, PIK3R1, RASA1, SRC, src, BTK, CBL, CDK1, CREBBP, DHX9, EMG1, FNBP4, FYN, GRAP, GRAP2, GRB2, HCK, HNRNPK, INSR, ITK, JAK3, KHDRBS1, KHDRBS3, LCK, LYN, MAPK1, NCF1, NCK1, PIK3R1, PLCG1, PLCG2, PRMT1, PTK6, PTPN6, RAPSN, RASA1, SMAD2, SMARCA2, SRC, STAT3, STUB1, TU
• Immunogen: The immunogen for anti-KHDRBS1 antibody: synthetic peptide directed towards the N terminal of human KHDRBS1
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Bovine: 100%; Dog: 100%; Horse: 100%; Human: 100%; Rabbit: 100%
• Peptide Sequence: Synthetic peptide located within the following region: LPELMAEKDSLDPSFTHAMQLLTAEIEKIQKGDSKKDDEENYLDLFSHKN
• Blocking Peptide: For anti-KHDRBS1 antibody is Catalog # AAP40665 (Previous Catalog # AAPY00917)
• Key Reference: Duran,A., (2008) Cancer Cell 13 (4), 343-354
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-KHDRBS1 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
• Storage Buffer: After reconstitution buffer contains 2% sucrose, PBS, and 0.1% sodium azide.

Product Protocols: KHDRBS1 antibody tested with Human Fetal Heart Tissue (ARP40665_P050)

Aviva Systems Biology is the original manufacturer of this KHDRBS1 antibody (ARP40665_P050)

Click here to view the KHDRBS1 antibody Western Blot Protocol

Product Datasheet Link: KHDRBS1 antibody (ARP40665_P050)

WB Suggested Anti-KHDRBS1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Fetal Heart

Western Blot image:


Description of Target: KHDRBS1 recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, KHDRBS1 functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. KHDRBS1 play a role in G2-M progression in the cell cycle. It represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. KHDRBS1 also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.

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Aviva Systems Biology’s KHDRBS1 antibody (ARP40665_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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