TSHR Antibody - N-terminal region (ARP41870_T100)

Catalog No: ARP41870_T100

25 ug of the indicated Human whole cell or tissue extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. The peptide is present in isoforms of 87, 31 and 28 kDa. Only the 28 kDa isoform is detected in these samples.

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TSHR
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 77%; Rat: 79%; Sheep: 100%
• Peptide Sequence: Synthetic peptide located within the following region: CHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISR
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-TSHR (ARP41870_T100) antibody is Catalog # AAP41870 (Previous Catalog # AAPP24407)
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that TSHR is expressed in Jurkat

• Enhanced Validation:

  Relative Expression (Western Blot)

• Reference: Claus,M., (2005) Endocrinology 146 (12), 5197-5203

Target Info

• Gene Symbol: TSHR
• Gene Full Name: Thyroid stimulating hormone receptor
• Alias Symbols: LGR3, CHNG1, hTSHR-I
• NCBI Gene Id: 7253
• Protein Name: Thyrotropin receptor
• Description of Target: TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5).
• Uniprot ID: Q96GT6
• Protein Accession #: NP_001018046
• Nucleotide Accession #: NM_001018036
• Protein Size (# AA): 764
• Molecular Weight: 87 kDa
• Protein Interactions: ADRB2; SCRIB; UBC; TSHB; RABAC1; GNA13; GNA12; FLNB; TSHR; GNAQ; PIK3R1; LHCGR; JAK2; JAK1; GNAI3; GNAI2; GNAS; GNA11; GNAO1; GNAI1; HSPA5; FN1; CANX; CALR; STAT3; CALCR;