TLR2 antibody - C-terminal region (ARP30551_P050)

Catalog#: ARP30551_P050

• Size: 50ug

Human Fetal Brain

Human liver

human lung

Human thymus

human macrophages

• Description of Target: TLR2 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Gene Symbol: TLR2
• Official Gene Full Name: Toll-like receptor 2
• Alias Symbols: CD282; TIL4
• Protein Accession#: NP_003255
• Nucleotide Accession#: NM_003264
• Swissprot Id: O60603
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 784
• Molecular Weight: 90kDa
• Application: WB, IHC
• Partner Proteins: AKT1, BMPR2, CD40, CHUK, MAP2K4, MAP3K14, NFKB1, NFKB2, REL, RELA, RIPK1, TNIP2, TRAF2, TRAF6, AKT1, CHUK, KSR2, MAP2K1, MAP2K4, MAP3K14, NFKB1, NFKB2, REL, RELA, TNIP2, TRAF2
• Immunogen: The immunogen for anti-TLR2 antibody: synthetic peptide directed towards the C terminal of human TLR2
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Horse: 92%; Bovine: 90%; Mouse: 90%; Sheep: 90%; Rat: 85%; Chicken: 84%; Dog: 84%; Goat: 84%; Pig: 78%
• Peptide Sequence: Synthetic peptide located within the following region: LEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
• Blocking Peptide: For anti-TLR2 antibody is Catalog # AAP30551 (Previous Catalog # AAPP01203)
• Key Reference: Niebuhr,M., (2008) Allergy 63 (6), 728-734
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-TLR2 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Review: TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages for immunohistochemistry

Product Review: TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages for immunohistochemistry

TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages

TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages

1) Antibody cataloged

ARP30551_P050 TLR 2 C terminal

2) What application tested?

IFA(primary antibody ARP30551_P050/secondary FITC-conjugated anti-rabbit[green])

3) What species sample type?

Human

4) What cell/tissue type?

Human macrophages

5) What dilution did you use?

1/200

6) Overall performance of antibody

very strong and clear signal

Data submitted by: Milan Fiala at UCLA