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TLR2 antibody - C-terminal region (ARP30551_P050)

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100 ul
$289.00
In Stock
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Gene Symbol:
TLR2
NCBI Gene Id:
7097
Official Gene Full Name:
Toll-like receptor 2
Protein Name:
Toll-like receptor 2
Swissprot Id:
O60603
Protein Accession #:
NP_003255
Nucleotide Accession #:
NM_003264
Alias Symbols:
CD282, TIL4
Description of Target:
TLR2 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
784
Molecular Weight:
90kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TLR2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TLR2.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human TLR2
Species Reactivity:
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rat, Sheep, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 91%; Dog: 85%; Goat: 85%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Mouse: 91%; Rat: 92%; Sheep: 91%; Zebrafish: 100%
Complete computational species homology data:
Anti-TLR2 (ARP30551_P050)
Peptide Sequence:
Synthetic peptide located within the following region: LEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
ATG16L1; IRF3; CREBBP; CLEC7A; CLEC4M; TIRAP; MAPK8IP3; TICAM1; TOLLIP; TLR10; TLR6; LY96; RIPK2; TRIP6; MYD88; RAC1; TLR1; IRAK1; HSP90B1; HRAS; SFTPA1; PIK3R1; HMGB1; CD14; TLR2;
Blocking Peptide:
For anti-TLR2 (ARP30551_P050) antibody is Catalog # AAP30551 (Previous Catalog # AAPP01203)
Datasheets / Downloads:
Printable datasheet for anti-TLR2 (ARP30551_P050) antibody
Target Reference:
Niebuhr,M., (2008) Allergy 63 (6), 728-734
Additional Product Images:

Product Review: TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages for immunohistochemistry

Product Review: TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages for immunohistochemistry

TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages

TLR2 Antibody – C terminal region (ARP30551_P050) for human macrophages

1) Antibody cataloged

ARP30551_P050 TLR 2 C terminal

2) What application tested?

IFA(primary antibody ARP30551_P050/secondary FITC-conjugated anti-rabbit[green])

3) What species sample type?

Human

4) What cell/tissue type?

Human macrophages

5) What dilution did you use?

1/200

6) Overall performance of antibody

very strong and clear signal

Data submitted by: Milan Fiala at UCLA

 
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