THRB Antibody - N-terminal region (ARP35636_P050)

Catalog No: ARP35636_P050

WB Suggested Anti-THRB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human muscle

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human THRB
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 86%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Rabbit: 79%; Rat: 79%
• Peptide Sequence: Synthetic peptide located within the following region: LHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTF
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-THRB (ARP35636_P050) antibody is Catalog # AAP35636 (Previous Catalog # AAPP07883)
• Reference: Horkko,T.T., et al., (2006) Int. J. Cancer 118 (7), 1653-1659

Target Info

• Gene Symbol: THRB
• Gene Full Name: Thyroid hormone receptor, beta
• Alias Symbols: GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA
• NCBI Gene Id: 7068
• Protein Name: Thyroid hormone receptor beta
• Description of Target: THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far.
• Uniprot ID: P10828
• Protein Accession #: NP_000452
• Nucleotide Accession #: NM_000461
• Protein Size (# AA): 461
• Molecular Weight: 53kDa
• Protein Interactions: NSD1; NCOA1; RANBP9; NCOR1; RXRA; THRB; MMS19; ADAT3; NCOA2; C1D; NCOA3; ATF2; ANP32A; SUMO1; SUMO2; ROBO4; MED21; HMGN3; EIF3I; NRIP1; RXRG; RXRB; CAMK2B; TBL1XR1; NCOR2; HDAC3; SMC1A; XRCC5; TBL1X; PRKDC; LIG3; HSPA4; GPS2; XRCC6; PARP1; LRIF1; SRC; PSM