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Datasheets/Manuals | Printable datasheet for anti-OSMR (ARP46396_P050) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human, Dog, Guinea Pig, Horse, Rabbit |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human OSMR |
Purification | Affinity Purified |
Predicted Homology Based on Immunogen Sequence | Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Rabbit: 92% |
Peptide Sequence | Synthetic peptide located within the following region: LLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYH |
Concentration | 0.5 mg/ml |
Blocking Peptide | For anti-OSMR (ARP46396_P050) antibody is Catalog # AAP46396 (Previous Catalog # AAPP27180) |
Subunit | beta |
Reference | Arita,K., (2008) Am. J. Hum. Genet. 82 (1), 73-80 |
Gene Symbol | OSMR |
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Gene Full Name | Oncostatin M receptor |
Alias Symbols | OSMRB, PLCA1, IL-31RB, OSMRbeta, IL-31R-beta |
NCBI Gene Id | 9180 |
Protein Name | Oncostatin-M-specific receptor subunit beta |
Description of Target | Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Uniprot ID | Q99650 |
Protein Accession # | NP_003990 |
Nucleotide Accession # | NM_003999 |
Protein Size (# AA) | 979 |
Molecular Weight | 110kDa |
Protein Interactions | UBC; CUL5; GAPDH; IL6ST; OSM; JAK2; JAK1; ERBB2; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "OSMR Antibody - middle region (ARP46396_P050)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Dog, Guinea Pig, Horse, Rabbit".
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How long will it take to receive "OSMR Antibody - middle region (ARP46396_P050)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "OSMR Antibody - middle region (ARP46396_P050)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "OSMR Antibody - middle region (ARP46396_P050)"?
This target may also be called "OSMRB, PLCA1, IL-31RB, OSMRbeta, IL-31R-beta" in publications.
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What is the shipping cost for "OSMR Antibody - middle region (ARP46396_P050)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "OSMR Antibody - middle region (ARP46396_P050)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "OSMR Antibody - middle region (ARP46396_P050)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "110kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "OSMR Antibody - middle region (ARP46396_P050)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "OSMR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "OSMR"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "OSMR"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "OSMR"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "OSMR"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "OSMR"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.