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NR2E3 Antibody - N-terminal region (ARP39069_T100)
Datasheets/Manuals | Printable datasheet for anti-NR2E3 (ARP39069_T100) antibody |
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Tested Species Reactivity | Human |
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Predicted Species Reactivity | Human, Mouse, Rat, Cow, Pig |
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Clonality | Polyclonal |
Host | Rabbit |
Application | WB |
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human NR2E3 |
Purification | Protein A purified |
Predicted Homology Based on Immunogen Sequence | Cow: 86%; Human: 100%; Mouse: 93%; Pig: 79%; Rat: 93% |
Peptide Sequence | Synthetic peptide located within the following region: METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVC |
Concentration | 1.0 mg/ml |
Blocking Peptide | For anti-NR2E3 (ARP39069_T100) antibody is Catalog # AAP39069 (Previous Catalog # AAPS04208) |
Reference | Hayashi,T., Ophthalmology 112 (12), 2115 (2005) |
Publications | Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 7, 10662 (2017). 28878246 Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. EMBO Mol Med. 4, 52-67 (2012). 22174013 |
Description |
Gene Symbol | NR2E3 |
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Gene Full Name | Nuclear receptor subfamily 2, group E, member 3 |
Alias Symbols | PNR, RNR, rd7, ESCS, RP37 |
NCBI Gene Id | 10002 |
Protein Name | Photoreceptor-specific nuclear receptor |
Description of Target | NR2E3 is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. NR2E3 is a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome.This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Uniprot ID | Q9Y5X4 |
Protein Accession # | NP_055064 |
Nucleotide Accession # | NM_014249 |
Protein Size (# AA) | 410 |
Molecular Weight | 45kDa |
Protein Interactions | BCL11A; SIN3A; DHX30; TBL3; MYBBP1A; NCOR1; HDAC3; RBL1; RBBP7; RBBP4; HDAC1; CDK9; VDR; DEDD2; RBFOX2; IRF9; ZNF232; SNAPC1; PPARG; HOXC13; NR3C1; ELAVL2; POLR3D; RARA; NR1D1; CRX; RXRB; RXRA; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "NR2E3 Antibody - N-terminal region (ARP39069_T100)"?
The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Pig".
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How long will it take to receive "NR2E3 Antibody - N-terminal region (ARP39069_T100)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
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What buffer format is "NR2E3 Antibody - N-terminal region (ARP39069_T100)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "NR2E3 Antibody - N-terminal region (ARP39069_T100)"?
This target may also be called "PNR, RNR, rd7, ESCS, RP37" in publications.
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What is the shipping cost for "NR2E3 Antibody - N-terminal region (ARP39069_T100)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "NR2E3 Antibody - N-terminal region (ARP39069_T100)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "NR2E3 Antibody - N-terminal region (ARP39069_T100)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "45kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "NR2E3 Antibody - N-terminal region (ARP39069_T100)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "NR2E3"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "NR2E3"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "NR2E3"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "NR2E3"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "NR2E3"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "NR2E3"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.