FRS3 Antibody - middle region (ARP52228_P050)

Catalog No: ARP52228_P050

WB Suggested Anti-FRS3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: DU145 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FRS3
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: GFPDGEEDETPLQKPTSTRAAIRSHGSFPVPLTRRRGSPRVFNFDFRRPG
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-FRS3 (ARP52228_P050) antibody is Catalog # AAP52228 (Previous Catalog # AAPP35638)
• Reference: Huang,L., (2006) Oncogene 25 (49), 6457-6466

Target Info

• Gene Symbol: FRS3
• Gene Full Name: Fibroblast growth factor receptor substrate 3
• Alias Symbols: SNT2, FRS2B, SNT-2, FRS2beta, FRS2-beta
• NCBI Gene Id: 10817
• Protein Name: Fibroblast growth factor receptor substrate 3
• Description of Target: FRS3 is an adapter protein that links FGR and NGF receptors to downstream signaling pathways. FRS3 is involved in the activation of MAP kinases. FRS3 down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: O43559
• Protein Accession #: NP_006644
• Nucleotide Accession #: NM_006653
• Protein Size (# AA): 492
• Molecular Weight: 54kDa
• Protein Interactions: NOTCH2NL; RFX6; SPERT; ADAMTSL4; SH3KBP1; CD2AP; SPRY2; TRIP6; TCF4; PLSCR1; GATA1; ERBB2; CBL; AES; ELAVL1; RND1; KARS; BMPR2; NTRK2; PRKCI; NTRK1; MAPK1; PTPN11; FGFR1; GRB2;