PPARGC1A antibody - N-terminal region (ARP31507_P050)

Catalog#: ARP31507_P050

• Size: 50ug

Human Jurkat

• Description of Target: PPARGC1A is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Gene Symbol: PPARGC1A
• Official Gene Full Name: Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
• Alias Symbols: LEM6; PGC-1(alpha); PGC-1v; PGC1; PGC1A; PPARGC1
• Protein Accession#: NP_037393
• Nucleotide Accession#: NM_013261
• Swissprot Id: Q9UBK2
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 798
• Molecular Weight: 91kDa
• Application: WB
• Partner Proteins: HIF1A, CDKN1B, COPS6, S100A7, BCL3, CDKN1B, COPS2, COPS3, COPS4, COPS6, COPS7A, COPS8, CUL5, ERN1, ESR1, F2RL1, GFER, GFI1B, GPS1, HAND2, HIF1A, HNF4A, HNF4G, JUN, JUND, MIF, NCOA1, NR4A2, NR4A3, PPARG, RNF139, RORA, S100A7, SMAD2, SMAD4, TP53, TXN, UCHL1, BCL3, BTBD2, CDKN1B, COPS2, COPS3, COPS4,
• Immunogen: The immunogen for anti-PPARGC1A antibody: synthetic peptide directed towards the N terminal of human PPARGC1A
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Chicken: 100%; Human: 100%; Rat: 100%; Bovine: 92%; Dog: 92%; Goat: 92%; Horse: 92%; Mouse: 92%; Pig: 92%; Rabbit: 92%
• Peptide Sequence: Synthetic peptide located within the following region: PSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQL
• Blocking Peptide: For anti-PPARGC1A antibody is Catalog # AAP31507 (Previous Catalog # AAPP02269)
• Key Reference: Vimaleswaran,K.S., (er) J. Appl. Physiol. (2008) In press
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-PPARGC1A antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: PPARGC1A antibody tested with Human Jurkat Cells (ARP31507_P050)

Aviva Systems Biology is the original manufacturer of this PPARGC1A antibody (ARP31507_P050)

Click here to view the PPARGC1A antibody Western Blot Protocol

Product Datasheet Link: PPARGC1A antibody (ARP31507_P050)

WB Suggested Anti-PPARGC1A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat

Western Blot image:


Description of Target: PPARGC1A is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s PPARGC1A antibody (ARP31507_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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Product Review: PPARGC1A antibody - N-terminal region (ARP31507_P050) in Mouse retina using IF

Product Page for PPARGC1A antibody - N-terminal region (ARP31507_P050)

Researcher: Dr. Joshua Sanes
Application: IF
Species+tissue/cell type: Mouse retina
Primary antibody dilution:1:200
Secondary antibody: Donkey anti rabbit-Cy3
Secondary antibody dilution: 1:1000