Catalog No: ARP45039_P050
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ARP45039_P050
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Datasheets/ManualsPrintable datasheet for anti-ACVR1 (ARP45039_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Goat, Guinea Pig, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human ACVR1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Goat: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: EGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSP
Concentration0.5 mg/ml
Blocking PeptideFor anti-ACVR1 (ARP45039_P050) antibody is Catalog # AAP45039 (Previous Catalog # AAPP12327)
ReferenceKariyawasam,H.H., (2008) Am. J. Respir. Crit. Care Med. 177 (10), 1074-1081
Gene SymbolACVR1
Gene Full NameActivin A receptor, type I
Alias SymbolsFOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2
NCBI Gene Id90
Protein NameActivin receptor type-1
Description of TargetActivin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Uniprot IDQ04771
Protein Accession #NP_001096
Nucleotide Accession #NM_001105
Protein Size (# AA)509
Molecular Weight55kDa
Protein InteractionsUBC; USP15; BMPR1A; ACVR1; INHBA; ACVR2A; PEG10; SMAD6; SMAD7; BAMBI; SMURF1; IGSF1; TSC22D1; TGFBR1; DCAF6; FGD6; FCHO1; PLEK; TTC17; RHEBL1; WDR61; RASL12; RASD2; PLEKHJ1; CDK14; NEK8; DUSP13; NUAK2; FKBP4; RAB6B; RAB17; UBXN1; FBXO30; RHOJ; PLEKHB1; UB
  1. What is the species homology for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Goat, Guinea Pig, Horse, Pig, Rabbit".

  2. How long will it take to receive "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "ACVR1 Antibody - N-terminal region (ARP45039_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?

    This target may also be called "FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2" in publications.

  5. What is the shipping cost for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "55kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ACVR1 Antibody - N-terminal region (ARP45039_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ACVR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ACVR1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ACVR1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ACVR1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ACVR1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ACVR1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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