TCF7L1 antibody - N-terminal region (ARP57917_P050)

Catalog#: ARP57917_P050

• Size: 50ug

Human 293T

Hum. Fetal Liver

Hum. Fetal Lung

• Description of Target: TCF7L1 participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. TCF7L1 down-regulates NQO1, leading to increased mitomycin c resistance.
• Gene Symbol: TCF7L1
• Official Gene Full Name: Transcription factor 7-like 1 (T-cell specific, HMG-box)
• Alias Symbols: TCF-3; TCF3
• Protein Accession#: NP_112573
• Nucleotide Accession#: NM_031283
• Swissprot Id: Q9HCS4
• Host: Rabbit
• Clonality: Polyclonal
• Protein Size (# AA): 588
• Molecular Weight: 63kDa
• Application: WB
• Partner Proteins: ALB, CTBP1, H3F3A, HIST4H4, NCOA3, PGR, RB1, TACC2, bel-1, tat, ACTN1, ACTN2, AR, BRCA2, CCND1, CDC25B, CIITA, CREBBP, CTBP1, CUX1, DACH2, EP300, ETV1, GATAD2A, GATAD2B, H3F3B, HIPK2, HMGN2, HNF1A, ING1, IRF1, IRF2, IRF7, JDP2, KAT2B, KLF13, MDM2, MECOM, MYOD1, NCOA1, NCOA3, NCOA4, NFE4, NOTCH1, NO
• Immunogen: The immunogen for anti-TCF7L1 antibody: synthetic peptide directed towards the N terminal of human TCF7L1
• Product Format: Lyophilized powder
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Mouse: 85%; Rabbit: 85%
• Peptide Sequence: Synthetic peptide located within the following region: ESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPG
• Blocking Peptide: For anti-TCF7L1 antibody is Catalog # AAP57917 (Previous Catalog # AAPP32328)
• Key Reference: Hillier,L.W., (2005) Nature 434 (7034), 724-731
• Reconstitution and Storage: Add 50 μl of distilled water. Final anti-TCF7L1 antibody concentration is 1 mg/ml in PBS buffer. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.

Product Protocols: TCF7L1 antibody tested with Human 293T Cells (ARP57917_P050)

Aviva Systems Biology is the original manufacturer of this TCF7L1 antibody (ARP57917_P050)

Click here to view the TCF7L1 antibody Western Blot Protocol

Product Datasheet Link: TCF7L1 antibody (ARP57917_P050)

WB Suggested Anti-TCF7L1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: 293T

Western Blot image:


Description of Target: TCF7L1 participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. TCF7L1 down-regulates NQO1, leading to increased mitomycin c resistance.

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Aviva Systems Biology’s TCF7L1 antibody (ARP57917_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

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