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100 ul
$289.00
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PIAS3 antibody - middle region (ARP32763_P050)

Description of Target:
PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family. It also activates TGF-beta/SMAD transcriptional responses. This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Gene Symbol:
PIAS3
Official Gene Full Name:
Protein inhibitor of activated STAT, 3
NCBI Gene Id:
10401
Alias Symbols:
FLJ14651; ZMIZ5
Tissue Tool:
Find tissues and cell lines supported to express PIAS3.
Protein Accession #:
NP_006090
Nucleotide Accession#:
NM_006099
Swissprot Id:
Q9Y6X2
Host:
Rabbit
Clonality:
Polyclonal
Protein Name:
E3 SUMO-protein ligase PIAS3
Protein Size (# AA):
628
Molecular Weight:
68kDa
Application:
WB
Protein Interactions:
UBC; HIC1; TRIM63; TRIM55; TAB2; SUMO1; CBS; SUMO2; SUMO3; STAT3; NCOA2; CREM; PRPF40A; SERPINA10; GEMIN4; UBE2I; SKIL; HNRNPK; ZFHX3; SERBP1; SATB1; ERBB4; Bcl11a; ELAVL1; PPP1CA; Grm7; Grm8; Grm6; Grm4; TRIM8; RAC1; C19orf60; CARHSP1; UBA1; PSMC1; TRIM2
Immunogen:
The immunogen for anti-PIAS3 antibody: synthetic peptide directed towards the middle region of human PIAS3
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Purification:
Affinity Purified
Complete computational species homology data:
PIAS3 antibody - middle region (ARP32763_P050)
Predicted Homology Based on Immunogen Sequence:
Human: 100%; Dog: 86%; Pig: 86%; Horse: 86%; Guinea pig: 86%; Rat: 79%; Bovine: 79%; Rabbit: 79%
Species Reactivity:
Human, Dog, Horse, Guinea pig, Bovine, Rabbit, Rat
Datasheets / Downloads:
Printable datasheet for
anti-PIAS3 antibody
- ARP32763_P050
Peptide Sequence:
Synthetic peptide located within the following region: DEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQGGDPSENKKK
Blocking Peptide:
For anti-PIAS3 antibody is Catalog # AAP32763 (Previous Catalog # AAPP03778)
Target Reference:
Roukens,M.G., (2008) Mol. Cell. Biol. 28 (7), 2342-2357
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Product Protocols: PIAS3 antibody tested with Human Fetal Spleen Tissue (ARP32763_P050)

Aviva Systems Biology is the original manufacturer of this PIAS3 antibody (ARP32763_P050)

Click here to view the PIAS3 antibody Western Blot Protocol

Product Datasheet Link: PIAS3 antibody (ARP32763_P050)

WB Suggested Anti-PIAS3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Fetal Spleen

Western Blot image:


Description of Target: PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family. It also activates TGF-beta/SMAD transcriptional responses. This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Questions pertaining to this data can be directed to techsupport@avivasysbio.com

Aviva Systems Biology’s PIAS3 antibody (ARP32763_P050) has been tested using other cell lysates and tissues. To obtain more data about this antibody please email us at info@avivasysbio.com.

To order by phone call us at (888) 880-0001, fax us at (858) 552-6975 or send an email to info@avivasysbio.com. Aviva manufactures this antibody so we can offer the best price. Please contact us to request pricing information.

All of Aviva’s products are guaranteed for the applications and experimental sample types mentioned in the datasheet below. Are you curious if this product will work for you? Please contact us at techsupport@avivasysbio.com

 
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