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100 ul
$289.00
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RET antibody - C-terminal region (ARP30878_P050)

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Gene Symbol:
RET
NCBI Gene Id:
5979
Official Gene Full Name:
Ret proto-oncogene
Protein Name:
Proto-oncogene tyrosine-protein kinase receptor Ret
Swissprot Id:
P07949
Protein Accession #:
NP_000314
Nucleotide Accession #:
NM_000323
Alias Symbols:
CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Description of Target:
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Protein Size (# AA):
1114
Molecular Weight:
123kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RET.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RET.
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 90%; Horse: 100%; Human: 100%; Mouse: 90%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data:
Anti-RET (ARP30878_P050)
Peptide Sequence:
Synthetic peptide located within the following region: EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVK
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
NOTCH2NL; UBC; CBLC; PDLIM7; HSP90AA1; GRB2; CBL; RET; MCRS1; IKBKG; DOK3; DOK5; DOK4; DOK6; SHC3; FRS2; DOK2; AKAP5; CBLB; GAB1; DOK1; NRTN; MAPK3; GRB10; GRB7; GFRA1; MAPK8; GDNF; PTK2; SHC1; MAPK14; SRC; MAPK1; PRKAR2A; PTPN11; PLCG1; PIK3R1; CRK; STAT
Blocking Peptide:
For anti-RET (ARP30878_P050) antibody is Catalog # AAP30878
Datasheets / Downloads:
Printable datasheet for anti-RET (ARP30878_P050) antibody
 
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